Sulfarsphenamine is a methanesulfonic acid derivative that has been used in 1920s in the treatment of syphilis.

Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. Vanillin is a natural substance widely found in many plant species and often used in beverages, foods, cosmetics, and pharmaceutical products. Antioxidant and anticancer potential have been described for this compound. Vanillin has been classified as a bioantimutagen and is able to inhibit mutagenesis induced by chemical and physical mutagens in various cell systems. Vanillin, a selective agonist of TRPV1, has been shown to attenuate i.c.v. STZ and AlCl3+d-galactose induced experimental Alzheime's disease (AD).

Thymol, a monoterpene, obtained from thyme oil or other volatile oils, is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions to help reduce and prevent plaque and gingivitis. Recently was shown, that this substance was able to significantly reduce the oxidative stress associated with cataract. The results suggested that thymol might be a potential therapeutic approach in the prevention of diabetic complications through its aldose reductase enzyme inhibitory and antioxidant activities.

Neoarsphenamine and related compounds are sulfhydryl-binding agents which are tolerated by man. A large experience in the employment of this drug and its toxic manifestations exists as a result of its former use as an antisyphilitic agent. Tertiary syphilis was a common cause for mental health conditions. Also known as Neosalvarsan, it superseded Salvarsan due to its lower toxicity. Both arsenicals still carried significant risk of side-effects and were themselves replaced by penicillin in the 1940s. Neoarsphenamine was also used for the treatment of amebic dysentery.

Tricaine (MS-222, Tricaine-S), a water-soluble local anesthetic, is used commonly for sedation, immobilization, and anesthesia of poikilothermic animals and has been accepted as a common anesthetic for use in the cold-blooded animals. It has long been recognized as a valuable tool for the proper handling of these animals during manual spawning (fish stripping), weighing, measuring, marking, surgical operations, transport, photography, and research. Tricaine was developed by Merck as a sulfonated analog of benzocaine with high solubility in water. The main advantage of Tricaine is the short duration of action and rapid metabolism. There are many reports describing the use of Tricaine for anesthetizing poikilothermic animals because it is a safe agent for immersion anesthesia even though the other anesthetics such as ether, ethanol, thiopental, halothane, isoflurane, barbiturates also could be used. Amphibians could be anesthetized easily by immersion methods with Tricaine because the amphibian skin is extremely permeable and water is absorbed through the skin rather than ingested. Tricaine has been administered as an injectable agent also.

Tolindate, a thiocarbamate, is a synthetic antifungal approved by FDA as an over-the-counter (OTC) drug product and is marketed by Norcliff Thayer Inc. It was prepared by treating 5-indanyl thionochloroformate with N-methyl-m-toluidine and patented in 1970 by USV Pharmaceutical Corporation tas a compound with strong topical antifungal activity that may be administered topically in the form of ointments and solutions. It was used in eastern Europe as Dalnate (USV Pharmaceutical Corporation trademark registerd in 6/26/1973) for topical application in the treatment of various dermatoses. Produced by ZORKA Pharma (at present Hemofarm a.d., Serbia) topical cream or solution Dalnate was registered for marketing in Russia.

Antimicrobial agent Fluorosalan is classified as Category II for use as antiseptic handwash, healthcare personnel handwash, patient preoperative skin preoperative skin preparation, and surgical hand scrub products. In the 1994 TFM (59 FR 31402 at 31435-31436), FDA proposed that the active ingredient fluorosalan be found not GRAS/GRAE for the uses referred to in the 1994 TFM as antiseptic hand wash and health care personnel hand wash.

This chemical compound was studied the Japan. According this investigation, there is no available information on toxicokinetics and metabolism of 6-tert-Butyl-m-cresol. The LD50 values for acute toxicity of this substance were between 320 and 800 mg/kg in males and between 130 and 320 mg/kg in females for rats, and 580 mg/kg in males and 740 mg/kg in females for mice. This substance is corrosive to skin and eyes in rabbits. However, no irritation problem has been reported at any production site where workers wear proper clothing and equipment. A reproductive toxicity study in rats revealed that this substance was toxic to the dams at 60 mg/kg, causing depression of body weight gain and a slight decrease in the number of corpora lutea and implantations. This effect in the dams influenced the outcome of pregnancy, seen as a decrease in the number of live births and depression of weight gain in the offspring. These effects were not seen at 12.5 mg/kg/day. No evidence of gross malformations was observed at any dose. Based on these findings, the NOAEL for reproductive toxicity is considered to be 12.5 mg/kg/day for both female parents and pups. Evidence of malformations was not observed at any dose.