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Search results for "JECFA" in comments (approximate match)
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(12)(i) laxative:bulk laxative guar gum
Source URL:
First approved in 1974
Source:
ANDA080767
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
US Previously Marketed
Source:
Castor Oil U.S.P.
(1921)
Source URL:
First marketed in 1921
Class:
STRUCTURALLY DIVERSE
Status:
US Previously Marketed
Source:
Tincture of Saffron N.F.
(1921)
Source URL:
First marketed in 1921
Source:
Tincture of Saffron N.F.
Source URL:
Class:
STRUCTURALLY DIVERSE
Conditions:
Saffron is a spice derived from the flower of Crocus sativus, commonly known as the "saffron crocus". Crocin is a water-soluble carotenoid pigment of saffron,that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. Saffron is now used worldwide in folk medicine and is reputed to be useful in treating various human disorders such as heart and blood disorders. Stroke and heart attack are involved in reputed folkloric uses of saffron. Saffron is orally administrated as a decoction. Saffron extract exerts a protective effect on renal ischemia reperfusion induced oxidative damage in rats. Crocin suppresses tumor necrosis factor (TNF) alpha-induced apoptosis of pheochromocytoma (PC12) cells by modulating mRNA expressions of Bcl-2 family proteins, which trigger downstream signals culminating in caspase-3 activation followed by cell death. Depriving cultured PC12 cells of serum/glucose causes a rapid increase in cellular ceramide levels, followed by an increase in the risk of cell death. The accumulation of ceramide was found to depend on the activation of neutral sphingomyelinase (nSMase). Crocin prevented the activation of nSMase by enhancing the transcription of gamma-glutamylcysteinyl synthase, which contributes to a stable glutathione supply that blocks the activity of nSMase.
Status:
Possibly Marketed Outside US
Source:
NCT02065076: Phase 4 Interventional Completed Hyperkalemia
(2014)
Source URL:
First approved in 2013
Source:
21 CFR 352
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Possibly Marketed Outside US
Source:
Sodium Fluoride 1.1% Dental Gel MINT by IPG PHARMACEUTICALS, INC.
(2025)
Source URL:
First approved in 2012
Source:
M020
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Possibly Marketed Outside US
Source:
M020
(2018)
Source URL:
First approved in 2009
Source:
21 CFR 350
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Possibly Marketed Outside US
First approved in 2009
Source:
21 CFR 352
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Possibly Marketed Outside US
Source:
M021
(2024)
Source URL:
First approved in 2005
Source:
Numark Multivitamins by NUMARK BRANDS, INC
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Possibly Marketed Outside US
First approved in 2001
Source:
Preferred Plus Urinary Pain Relief by Kinray
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
Possibly Marketed Outside US
Source:
NCT01426750: Phase 4 Interventional Completed Malnutrition
(2002)
Source URL:
First approved in 1996
Source:
ANDA091226
Source URL:
Class:
STRUCTURALLY DIVERSE
Conditions:
Phopsholipon is a well-established lipoid brand characterizes natural and hydrogenated lecithin fractions and phospholipids from soybean, rapeseed (canola) or sunflower for pharmaceutical oral or topical applications and for use in cosmetics, as well in emulsions; liposomal formulations; as natural oil replenishing agents in shampoos and bath additives. Applications: preparation of mixed micelles, liposomes and micro emulsions. Solubilizer for parenteral administration forms; emulsifier for pharmacy, dermatology and cosmetics; phosphatidylcholine source for drugs and dietetics.