U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 151 - 160 of 381 results

Status:
Designated
Source:
FDA ORPHAN DRUG:764720
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

JNJ-28312141 is an orally active colony-stimulating factor-1 receptor and FMS-related receptor tyrosine kinase-3 inhibitor. In preclinical models, JNJ-28312141 caused regression of ITD-FLT3–dependent MV-4-11 AML xenografts. The drug also suppressed the growth of H460 non-small cell lung adenocarcinoma xenografts and inhibited osteoclastogenesis and osteolysis in a rat model of metastatic bone disease.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Showing 151 - 160 of 381 results