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Search results for amphotericin root_names_name in Any Name (approximate match)
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
GRN-529 is a negative allosteric modulator of mGluR5. In a mouse model of autism, GRN-529 (named as PF-05212391 by Pfizer) decreased self-grooming and stereotyped jumping and increased social functioning compared with no treatment. In a mouse model of depression, GRN-529 had dose-dependent efficacy across a therapeutically relevant battery of animal models, comprising depression and 2 of the co-morbid symptoms overrepresented in treatment resistant depression, namely anxiety and pain