Skimmin is one of the major pharmacologically active compounds found in the traditional Chinese medicinal herb Hydrangea paniculata and H. macrophylla. Skimmin is a glycosylated coumarin and precursor in the biosynthesis of umbelliferone. Skimmin has been identified as a potential anti-inflammatory compound which may be of use in diabetic neuropathies such as membranous glomerulonephritis. It was also identified as a potent anti-amoebic compound found in the root bark of Adina cordifolia, a plant used in East Indian folk medicine.