Neochlorogenic acid is a natural polyphenolic compound which can be found in a variety of plant sources and especially some types of dried fruit. It is an epimer of chlorogenic acid. Neochlorogenic has been investigated as a chemopreventative dietary compound for breast cancer and collorectal cancer. It has in-vitro anti-inflammatory properties, and may be responsible for the laxative effect fo prunes. Research surrounding neochlorgenic acid has often involved various plant extracts, rather than pure preparations of the compound.

Cryptochlorogenic acid is a structural isomer of chlorogenic acid; it is a cinnamate ester formed by the condensation of the carboxy group of trans-caffeic acid with the 4-hydroxy group of quinic acid. It can be isolated from several plant sources including apples, coffee, sunflowers, potatoes, and Hibiscus sabdariffa. Cryptochlorogenic acid mixed with related compounds has demonstrated potential anti-oxidant and anti-inflammatory properties and shown inhibitory activity against HBV DNA replication.

4-p-coumaroylquinic acid is one of the most abundant components of Turkish black tea Camellia sinensis L possesses antioxidant properties.

Piperic Acid is a metabolite of Piperine. Piperic acid is found in herbs and spices. Piperic acid is obtained from black pepper (Piper nigrum), from Minthostachys verticillata, peppermint (Mentha piperita) and others. Piperic acid is an intermediate in the synthesis of other compounds such as piperonal, and as-such may be used to produce fragrances, perfumes flavorants and drugs as well as other useful compounds. The cytotoxic effects of piperic acid in prostate cancer cells (PC-3) and breast cancer cells (MDA-MB-231) were studied. The drug treatment experiments clearly indicated that maximum cytotoxicity was achieved at 48 hours and at 100uM concentration of piperic acid in both the cell lines. It is proposed that piperine might get metabolized into piperonylic acid, piperic acid, and piperonal in human as evidenced in rats. Hence, the three derivatives of piperine presented above shall be of therapeutic significance. Piperic Acid has revealed Lipoxygenase (LOX) inhibitory activity. The possibility of exploiting the higher LOX inhibitory activity and lower IC50 values of piperine derivatives, piperonal, and piperonylic acid, in various ways for therapeutic applications, especially with fermented herbal drugs containing materials with piperine as a constituent has being suggested.