Fluorine-18 labeled phenethylguanidines are currently under development as radiotracers for quantifying regional cardiac sympathetic nerve density using PET imaging techniques. [(18)F]4F-MHPG is a cardiac sympathetic nerve imaging agent with kinetic properties favorable for quantifying regional nerve density with PET and tracer kinetic analysis. .

Leonurine (LN) is a natural alkaloid extracted from Herba leonuri which is used in Chinese traditional medicine and possesses anti-inflammatory properties. Leonurine has potential as a therapeutic agent for rheumatoid arthritis and might be a promising therapeutic compound to treat osteoclast-related diseases, such as osteoporosis. These effects are achieved through the inhibition of NF-κB and mitogen-activated protein kinase pathways. In addition, it was found that leonurine protects BBB integrity by regulating the HDAC4/NOX4/MMP-9 tight junction pathway and could therfeore represent a new class of potential drugs against the acute onset of ischemic stroke. In experiments on mice with adenomyosis leonurine attenuated generalized hyperalgesia, however, the mechanism responsible for alleviating pain was not readily apparent.