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Manganomanganic oxide is an oxide of Mn (II,III) with is formula of Mn3O4. It was proposed as a food supplement for prevention of manganese deficiency in animals and fish. The manganomanganic oxide Elkem Agrimax contained a lead mixture, and because of it was not approved for animal use by Scientific Committee for Animal Nutrition
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
The selective serotonin reuptake inhibitor fluoxetine consists of equal amounts of R and S stereoisomers (antidepressant Prozac (racemic fluoxetine). Binding to the transporter confirmed selectivity of R- and S-fluoxetine for the 5-HT transporter versus the dopamine (DA) and norepinephrine (NE) human transporters. In addition, receptor binding studies demonstrated significant affinity of R-fluoxetine, but not S-fluoxetine, for human 5-HT(2A) and 5-HT(2C) receptor subtypes. R-fluoxetine acts as an antagonist at 5-HT(2A) and 5-HT(2C) receptors. The attempt to develop a single-enantiomer formulation of fluoxetine for the treatment of depression was unsuccessful. Eli Lilly has terminated its licensing and development agreement with Marlborough, Mass.-based Sepracor for (R)-fluoxetine, the single-isomer version of Lilly's antidepressant Prozac.R-enantiomer of fluoxetine, at its highest administered dose, led to statistically significant prolongation of cardiac repolarization in phase II studies; the studies were subsequently stopped.
There is no information about biological or pharmacological application of lead formate, this substance is used for proteomics research.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
AVE-0118 is a Kv1.5 blocker which was developed by Aventis Pharma for the treatment of cardiovascular diseases. The drug reached phase II of clinical trilas in patients with atrial fibrillation, however its development was terminated.
