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Search results for nonoxynol root_version in Record Version (approximate match)
Status:
Other
Class (Stereo):
CHEMICAL (UNKNOWN)
Targets:
Conditions:
TM30089 is a slective CRTH2 antagonist. TM30089, displayed high selectivity for and antagonistic potency on mouse CRTH2 but lacked affinity to TP and many other receptors including the related anaphylatoxin C3a and C5a receptors, selected chemokine receptors and the cyclooxygenase isoforms 1 and 2 which are all recognized players in allergic diseases. Furthermore, TM30089 and ramatroban, the latter used as a reference herein, similarly inhibited asthma pathology in vivo by reducing peribronchial eosinophilia and mucus cell hyperplasia.