U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1331 - 1340 of 6009 results

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

P7C3 is a chemical compound belongs to a class of proneurogenic compounds that are potential nicotinamide phosphoribosyltransferase (NAMPT) activators, and might shed light on future drug development in neurogenesis restoration. This compound protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. In addition on animal models was shown, that P7C3 is sufficient to restore the neurogenic deficits observed in the Ts65Dn mouse model of Down Syndrome, and also was discovered, that P7C3 might provide a basis for the discovery and optimization of pharmacologic agents for the treatment of amyotrophic lateral sclerosis (ALS) and for the treatment of patients with Parkinson disease (PD).

Showing 1331 - 1340 of 6009 results