trans-Ketoconazole was identified as impurity of an antifungal compound cis-ketoconazole. Cis-Ketoconazole displayed broad-spectrum in vivo activity in a wide range of experimental fungal infections caused by different fungi in a variety of animal models. trans-isomer of ketoconazole is less active than cis-ketoconazole.

Bromadiolone is a multi-feed, synthetic, second-generation anti-coagulant rodenticide. The active ingredient is formulated on a food base, typically cereal, to produce a ready to use bait containing 0.005% w/w bromadiolone. When compared to other anticoagulant rodenticides, bromadiolone has a good level of activity against the brown rat, and moderate levels of activity against mice. Bromadiolone is marginally more toxic to non-target 'farmyard' species than difenacoum. Bromadiolone is a potent poison to all mammal species and it is essential that all baits should be well protected from non-target animals. The best way to achieve this is by placing the baits in an approved bait box. Bromadiolone is a second-generation single-dose anticoagulant rodenticide. It disrupts the normal blood clotting mechanisms resulting in increased bleeding tendency and, eventually, profuse haemorrhage and death. Effectiveness of bromadiolone depends on exposure (i.e. consumption of the bait by the target organism).