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Restrict the search for
icosapent ethyl
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Doxapram is racemic and exists as a racemate with positive ( ) and negative (−) enantiomers. The respiratory stimulant properties of doxapram would be stereoselective and could be evaluated by chirally separating doxapram into its ( ) enantiomer (GAL-054) and (−) enantiomer (GAL-053). Pre-clinically we demonstrated that the ( ) enantiomer, GAL-054, and not the (−) enantiomer, GAL-053, dose-dependently increased minute volume when administered intravenously to drug naïve and opioid challenged rats and cynomolgus monkeys. Moreover, the deleterious side-effects of agitation and seizures were restricted to GAL-053. There were minimal
behavioral changes observed in rats and monkeys receiving GAL-054. Thus, GAL-054 is the eutomer and GAL-053 the distomer of doxapram. Unfortunately, in conscious rats GAL-054 increased blood pressure approximately 15–20% above baseline values at doses that were moderately respiratory stimulant. This effect was confirmed in a Phase 1 clinical trial evaluating the effects of GAL-054 in healthy volunteers (Galleon Pharmaceuticals, unpublished data). Thus, the ventilatory stimulant and pressor effects of doxapram cannot be separated by enantiomeric separation of the racemate.
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol (N,N-didesmethylvenlafaxine, also known as Venlafaxine EP Impurity C) is an intermediate in the synthesis of N,O-Didesmethylvenlafaxine and a metabolite of Venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI).
![Structure of (1S,2S)-2-[Benzyl(methyl)amino]-1-cyclohexylpropan-1-ol hydrochloride](/img/3df264bf-029c-46cc-b43b-f1ee9a7f903a.svg?size=200&context=envkxvemht)
