Potassium magnesium citrate has being proven to be an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. Liquid potassium magnesium citrate has being studied in clinical trial for controlling Hypertension. Provision of alkali as potassium-magnesium citrate is an effective countermeasure for the increased risk of renal stone disease associated with immobilization. Despite an increase in urine calcium concentration, the relative saturation of calcium oxalate decreased due to citrate chelation of calcium and the concentration of undissociated uric acid decreased due to the significant increase in urine pH. Potassium magnesium citrate is a nutritional supplement that fights kidney stones in three different ways. The potassium provided by the supplement raises the pH of the urine, making it more alkaline, thus reducing the amount of calcium that the urine can dissolve. When there is less calcium in the urine, fewer calcium kidney stones can form. The magnesium in the supplement reduces the amount of calcium the kidneys pump out of the body and into the urine. And the citrate in the supplement keeps oxalates dissolved in the urine so they are flushed away before they can form kidney stones.

Zuclomiphene Citrate is the cis isomer of clomiphene which exhibits weak estrogen agonist activity evaluated for antineoplastic activity against breast cancer. The individual isoforms are not available commercially, but Repros Therapeutics (The Woodlands, TX, USA) has separated them and is using enclomiphene citrate (ENC) in clinical trials in men with secondary hypogonadism who wish to preserve their fertility. Zuclomiphene, possessing no oestrogen antagonism at physiological concentrations, appears to have a longer biological half-life than enclomiphene, and thus may persist for long periods in the body. At high concentrations zuclomiphene can act as an oestrogen agonist. Clomiphene citrate (CC) is often used ‘off-label’ in men who have low testosterone to raise levels, it is also useful for the restoration of sperm counts in men. CC is approved by FDA and widely used in women for induction of ovulation for several conditions. CC is a mixture of two diastereoisomers, a cis isomer, zuclomiphene citrate (ZUC, 38%) and a trans isomer, ENC (62%). The two clomiphene isomers have mixed estrogenic and antiestrogenic effects that vary among species.