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Restrict the search for
telotristat ethyl
to a specific field?
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Pravadoline is the anti-nociceptive agent, which has analgesic efficacy against postoperative pain in humans. Pravadoline inhibits the enzyme cyclooxygenase, but in contrast to cyclooxygenase-inhibiting NSAIDs does not produce gastrointestinal irritation. Pravadoline inhibited the synthesis of prostaglandins in mouse brain both in vitro and ex vivo. Pravadoline demonstrated only weak anti-inflammatory activity relative to its anti-nociceptive potency. Single doses of pravadoline were safe and effective in humans, without serious adverse events. Single oral administration of pravadoline maleate induced acute tubular necrosis in male and female beagle dogs.
Status:
Investigational
Source:
INN:dexsecoverine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Dexsecoverine ia an antimuscarinic drug.
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Thimerfonate is a alkyl mercuric derivative with germicidal activity.
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Stilbazium is a pyridinium derivative with considerable anthelminthic activity against some animal nematodes, including Syphacia obvelata, Ancylostoma caninum, Uncinaria stenocephala and Toxocara cati.
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Probarbital is ethylisopropylbarbituric acid patented by Thorp, L as hypnotic and sedative agent.
Status:
Excipient
Source:
0.12mg ORAL TABLET
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Guinea green B is an organosulfur stain. It is used as a dye for silk and wool fabrics and as a biological stain.
Status:
Designated
Source:
FDA ORPHAN DRUG:877322
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Designated
Source:
FDA ORPHAN DRUG:930522
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Designated
Source:
FDA ORPHAN DRUG:568816
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Designated
Source:
FDA ORPHAN DRUG:550316
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
APC-3316 is a vinyl sulfone cystein protease inhibitor. It is a potent, irreversible cysteine protease inhibitor and a potent and selective CCR4 antagonist. Its therapeutic targets are cruzain, a cysteine protease of the protozoan parasite Trypanosoma cruzi, and cathepsins B and L, which are associated with cancer progression. It was discontinued after preclinical trials in Chagas disease in USA.
