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Development Status
Other
655
Possibly Marketed Outside US
155
Investigational
148
US Approved Rx
102
US Previously Marketed
55
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Primary Target
Histamine H1 receptor
10
Dopamine D2 receptor
9
Serotonin 2a (5-HT2a) receptor
7
Estrogen receptor beta
6
Estrogen receptor alpha
5
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Highest Phase
Approved
123
Phase III
17
Phase II
14
Phase I
5
Phase IV
1
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Approval Year
Unknown
842
1921
37
2012
15
2010
13
2009
12
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Condition
Hypertension
12
Unknown
11
Schizophrenia
9
Alzheimer’s disease
7
Cancer
7
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Treatment Modality
Primary
145
Curative
27
Palliative
27
Preventing
24
Diagnostic
8
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CNS Activity
CNS Active
60
CNS Penetrant
52
CNS Non-penetrant
23
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Originator
Eli Lilly
9
Novartis
7
AstraZeneca
5
Merck
5
GlaxoSmithKline
4
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Substance Class
Chemical
675
Structurally Diverse
209
Protein
198
Concept
33
Mixture
14
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INN Stem
Chemical substance(-ine)
5
Peptides and glycopeptides(-tide)
3
Antiviral drug(-vir)
1
Tyrosine-kinase inhibitors(-tinib)
1
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GInAS Tag
KEW
13
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Code System
FDA UNII
1,114
CAS
740
PUBCHEM
667
EPA CompTox
414
NCI_THESAURUS
350
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Protein Type
ENZYME
29
RECEPTOR
27
PEPTIDE
16
MONOCLONAL ANTIBODY
8
CYTOKINE
4
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ATC Level 1
NERVOUS SYSTEM
26
ALIMENTARY TRACT AND METABOLISM
25
CARDIOVASCULAR SYSTEM
18
ANTIINFECTIVES FOR SYSTEMIC USE
16
RESPIRATORY SYSTEM
12
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ATC Level 2
ANTIBACTERIALS FOR SYSTEMIC USE
10
PSYCHOANALEPTICS
10
PSYCHOLEPTICS
9
OPHTHALMOLOGICALS
8
ANTIHISTAMINES FOR SYSTEMIC USE
6
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ATC Level 3
ANTIDEPRESSANTS
8
ANTIHISTAMINES FOR SYSTEMIC USE
6
ANTIPSYCHOTICS
6
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
4
DIRECT ACTING ANTIVIRALS
4
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ATC Level 4
Antibiotics
5
Diazepines, oxazepines, thiazepines and oxepines
4
Non-selective monoamine reuptake inhibitors
4
Other antihistamines for systemic use
4
ACE inhibitors and calcium channel blockers
3
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Substance Form
Principal Form
1,049
Salts, Hydrates, Esters, etc.
65
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