U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Ipronidazole is an antiprotozoal drug of the nitroimidazole class used in veterinary medicine. Ipronidazole (2-isopropyl-1-methyl-5-nitroimidazole) is used for the treatment of histomoniasis in turkeys and in swine dysentery.
Status:
Possibly Marketed Outside US
Source:
Japan:Isoaminile Citrate
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Conditions:

Isoaminile is a cough suppressant that acts by influencing the cough centre.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Spasmolytic drug pramiverine was used in the active treatment of labor. In addition, it participated in clinical trials for patients with colitis syndrome. It was revealed, that pramiverine had improved the conditions of patients.
Status:
Possibly Marketed Outside US
Source:
Japan:Iproheptine Hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)



Iproheptine (Metron, Susat) is a vasoconstrictor, antihistamine, nasal decongestant marketed in Japan.
Status:
Possibly Marketed Outside US
Source:
Japan:Gallopamil Hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)



Gallopamil is a L-type calcium channel blocker designed for the treatment of coronary heart diseases: angina pectoris, prinzmetal angina and hypertonia.
Status:
Possibly Marketed Outside US
Source:
NCT00119145: Phase 4 Interventional Completed Malaria
(2005)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Chlorproguanil is a biguanide. Chlorproguanil is active against P. falciparum and P. malariae. Chlorproguanil acts by inhibition of dihydrofolate reductase after cytochrome P450-catalysed cyclization. Chlorproguanil combined with dapsone was developing for the treatment of falciparum malaria. The anti-malarial combination chloroproguanil and dapsone has been withdrawn following demonstration of post-treatment haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD) deficient patients in a phase III clinical trial.
Lorcainide is a class Ic antiarrhythmic medication. It was reported to be highly efficient for the treatment of ventricular arrhythmias, ventricular fibrillation, and tachycardia. The drug was used under the name Remivox. The mechanism of lorcainide action involves the blockage of sodium channels. Lorcainide was withdrawn from the market for a commercial reason, but later it was admitted that the use of the drug is associated with high risk of death.
Status:
Possibly Marketed Outside US
Source:
SPECTAMINE by Medi-Physics
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

Iofetamine is a diagnostic compound that was used for brain-imaging. Iofetamine may cause different adverse reactions such as increase in systolic blood pressure by about 10 mm Hg, dizziness, hearing loss and allergy.
Menthol, (+)- is a fragrance ingredient used in decorative cosmetics, fine fragrances, shampoos, toilet soaps and other toiletries as well as in non-cosmetic products such as household cleaners and detergents. Recent investigations have provided evidence for menthol to increase cough thresholds. Racementhol is used as a topical analgesic.