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Status:
Investigational
Source:
INN:maraciclatide [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Maraciclatide (NC100692 or diamine dioxime-Lys-Cys-Arg-Gly-Asp-Cyc-Phe-Cys-polyethylene glycol) is a cyclic peptide that contains an RGD tripeptide sequence held in a specific conformation by a disulphide and one thioether bridge. The ε-amino group of the lysine residue serves as an attachment point for the technetium chelator and the C-terminal end modified with a short polyethylene glycol unit. Cyclic RGD peptides such as this have a high affinity towards vitronectin receptors. Maraciclatide radiolabelled with technetium 99m (99mTc) is being developed as an in vivo diagnostic marker of vitronectin integrin receptor expression.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Mecrylate (metyl 2-cyanoacrylate) ) is a clear,
colorless liquid with a strong, acrid odor. In contact with hydroxide ions (liquids like blood or water, air humidity), the cyanoacrylates form long, strong and waterproof chains in an exothermic reaction. The resulting polymer leads to a stable adhesive bond. It may be used as tissue adhesive in surgery. Mecrylate is the first generation short-chain cyanoacrylate, it turned out to be histotoxic and caused distinct foreign-body reactions.
Status:
Investigational
Source:
INN:lunacalcipol [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Lunacalcipol (CTA-018 or MT-2832) is a vitamin D analog having a dual mechanism of action. It inhibits CYP24A1 and induced VDR expression. It was being developed for the treatment of clinical consequences of vitamin D insufficiency and secondary hyperparathyroidism associated with chronic kidney disease. Lunacalcipol development has been discontinued.
Status:
Investigational
Source:
INN:laurixamine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
LAURIXAMINE is a fungicide. It is an antibacterial, ophthalmologic agent.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Etazolate (EHT-0202) is a selective, positive GABAA receptor modulator has completed phase II clinical trials in patients with Alzheimer's disease. It is also a selective phosphodiesterase-4 inhibitor that is specific for cAMP. Etazolate showed anxiolytic and antidepressant activity and could be useful in managing post-traumatic stress disorder.
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Eterobarb (Antilon) is a barbiturate derivative. It is an effective anticonvulsant as demonstrated
in animal and clinical studies. Eterobarb possesses a unique and clinically intriguing
feature-at therapeutically effective blood levels, the hypnotic side effects usually associated
with barbiturates appear absent. Though effective
against both electrically and chemically induced
seizures in mice and rats, virtually no hypnotic effects were
noted except at lethal doses. Double-blind
cross-over studies have confirmed the anticonvulsant
efficacy of eterobarb and
several phase II and phase Ill studies show eterobarb
to be an effective anticonvulsant with less
hypnotic activity when compared with phenobarbital.
Eterobarb had been NDA filed for the treatment of epilepsy in the US, UK, Switzerland and Canada. However, this research has been discontinued. The compound was originated by Colgate Palmolive, then licensed to MacroChem.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Esuprone (LU 43839) is a monoamine oxidase type A inhibitor. Esuprone proved to be an effective anticonvulsant in the kindling model. Esuprone was undergoing phase II clinical trials with Knoll (BASF Pharma) in Germany as an antidepressant.
Class (Stereo):
CHEMICAL (RACEMIC)
Moxnidazole is an antiparasitic drug suitable for oral use against parasites in farm animals. administration of Moxnidazole in the drinking water gave good prophylaxis of dysentery in swine, histomoniasis in hens and turkeys, and trichomoniasis in pigeons. Isolated relapses were due to renfections and were successfully treated by another dose of the drug.
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
FLAVODILOL is an antihypertensive agent.