U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 15391 - 15400 of 141793 results

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Schisandrins (schizandrins) are a group of bioactive chemical compounds found in Schisandra chinensis, one member of which is Schisandrin C. Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes via cAMP/PKA/CREB and Nrf-2 signaling. Also was shown, that among human hepatocellular carcinoma cells (Bel-7402), human breast cancer cells (Bcap37) and human nasopharyngeal carcinoma cells (KB-3-1), Bel-7402 cells were most sensitive with IC50 equal to 81.58 ± 1.06 μ M after treatment with schisandrin C. Although the mechanism of tumor inhibiting activity of schisandrin C is not clarified, there are some reports about dibenzocyclooctadiene lignans inducing cancer cell apoptosis. Further investigations are needed to determine in more detail the molecular mechanism, such as the dependent pathway of this apoptotic process, the signal transduction pathways involved and the possible changes in expression of other apoptosis-related genes. Recently was also speculated, that Schisandrin C offered protection against Aβ1-42 -induced dysfunction in learning and memory by inhibiting total cholinesterase and its antioxidant action.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Showing 15391 - 15400 of 141793 results