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Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
JTE-907 is selective high-affinity cannabinoid CB2 receptor inverse agonist. JTE-907 showed a concentration-dependent increase of forskolin-stimulated cAMP production in CHO cells expressing human and mouse CB2 in vitro. In mice model of atopic dermatitis, JTE-907 suppresses spontaneous itch-associated responses of NC mice without adverse effects such as weight loss.