NSC-87877 is a potent inhibitor shp2 and shp1 protein tyrosine phosphatases (PTP). Molecular modeling and site-directed mutagenesis studies suggested that NSC-87877 binds to the catalytic cleft of Shp2. In addition, NSC-87877 inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. In addition, NSC-87877 possesses ability to inhibit the dual-specificity protein phosphatase 26 (DUSP26). Active DUSP26 causes inactivation of p38 and p53 with their respective downstream proapoptic proteins, resulting in tumor growth. The addition of NSC-87877 results in competitive inhibition of DUSP26 activity and removes the inhibitory effect of DUSP26 on p38 and p53. Because DUSP26 is involved in survival of anaplastic thyroid cancer (ATC) cells, NSC-87877 could be a therapeutic reagent for treating ATC. In addition was shown on animal models, that NSC-87877 could be effective strategy against neuroblastoma.