D-aspartic acid is an essential amino acid and a key ingredient in various testosterone boosting anti-estrogen supplements. D-aspartic acid is not used to build proteins; instead, it plays a role in making and releasing hormones in the body. It is an endogenous NMDA receptor agonist with similar activity to the L-isomer. D-aspartic acid also enhances the release of luteinizing hormone (LH) and testosterone. This action is mediated in the pituitary by cGMP and in the testis by cAMP, which acts as the second messengers in the signal transduction in the pituitary and testes respectively. The pituitary and testis possess a D-Aspartate racemase, which provides the necessary production of this isomer.

Oryzanol A (gamma-oryzanol) is a naturally occurring component in rice bran and rice germ which consists of a mixture of ferulic acid esters of sterols and triterpene alcohols. In 1954, Kaneko and Tsuchiya et al. reported that isolated oryzanol demonstrated nutritional effects on animals. There are increasing numbers of reports indicating the benefits, efficacy and safety of gamma-oryzanol. There are a number of clinical studies reported that gamma-oryzanol is beneficial in the treatment of relieving menopausal (climacteric) symptoms. combination of -oryzanol and plant sterol has been used in the treatment of senile dementia, arteriosclerosis and cerebromalacia. The mechanism of action of gamma-oryzanol is believed to be involved in the metabolism of catecholamine in the hypothalamus. The antioxidant effect of gamma-oryzanol was well documented and excellent in inhibiting lipid peroxidation. Currently in Japan, gamma-oryzanol is approved and listed as “antioxidant” under the list of chemical composition of food additives. Oryzanol A has been shown to alleviate hypercholesterolemia and hyperlipidemia.