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Primary Target

cholesterol biosynthetic process

4

Histamine H1 receptor

315

Dopamine D2 receptor

297

DNA

278

Bacterial penicillin-binding protein

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Dengue virus infection

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Lipid metabolism disorders

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Pfizer

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PUBCHEM

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Showing 1 - 4 of 4 results

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ETOMOXIR FREE ACID

5HH4PR8XLD

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

cholesterol biosynthetic process

PF-429242

49WB3OA7VN

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Membrane-bound transcription factor site-1 protease

Hepatitis C virus

cholesterol biosynthetic process

Conditions:

Dengue virus infection

Lipid metabolism disorders

The small molecule PF-429242 was developed as a hypolipidemic agent based on high throughput screening in a Pfizer compound library. PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.1...

75 uM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 uM). PF-429242 inhibits the activity of S1P reversibly and competitively and suppresses the expression level of SREBP target genes, consequently decreasing cellular lipid levels. It has been shown that PF-429242 suppresses hepatic SREBP target genes and inhibits cholesterol and fatty acid synthesis in a mouse model. It also has been reported that PF-429242 suppresses viral replication in cells infected with hepatitis C virus (HCV), Lassa virus, lymphocytic choriomeningitis virus, New World arenaviruses and Dengue virus.

ETOMOXIR FREE ACID SODIUM MONOHYDRATE

AN6577AM7P

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

cholesterol biosynthetic process

ETOMOXIR FREE ACID SODIUM

Z6MN4UHR8S

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

cholesterol biosynthetic process

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