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Receptor-type tyrosine-protein phosphatase C

2

Histamine H1 receptor

315

Dopamine D2 receptor

297

DNA

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Bacterial penicillin-binding protein

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Unknown

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Originator

Barbara Ann Karmanos Cancer Institute; Dekk-Tec

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SIVIFENE

XAV05295I5

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Receptor-type tyrosine-protein phosphatase C

Sivifene (also known as A-007), a triaryl hydrazone that produced objective responses when applied topically. During preclinical studies, sivifene was observed to upregulate both cutaneous and systemic T-lymphocytes, in particular, CD4/8+ lymphocyte ...

subtypes. The current mechanism of action for the drug is unknown however is assumed that it can show its immunomodulating properties through the upregulation of the CD45 T lymphocyte cell surface receptor. Sivifene was being evaluated for its anticancer activities in melanoma, breast cancer, Kaposi's sarcoma, and lymphoproliferative disorders. The drug as a 0.25% gel is confirmed as an effective palliative treatment option for cutaneous metastases from cancers. Skin reactions were minimal, tolerated, and no cessation of treatment was required. However, the further development of this drug apparently has been discontinued.

ASTRAGALOSIDE II

0K5J34DHEN

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

mTOR signaling pathway

Receptor-type tyrosine-protein phosphatase C

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