U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 3 of 3 results

Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



Defactinib is an oral, investigational drug candidate for the treatment of various solid tumors. Through dual inhibition of FAK and PYK2, defactinib targets key resistance mechanisms in the tumor microenvironment (TME), including limited local immune...
Malonoben is a synthetic inhibitor of protein tyrosine kinase (PTK) that displays characteristics of a potent reversible inhibitor of platelet-derived growth factor (PDGF)-induced mitogenesis via inhibition of tyrosine kinase activity of the PDGFR (P...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



Defactinib is an oral, investigational drug candidate for the treatment of various solid tumors. Through dual inhibition of FAK and PYK2, defactinib targets key resistance mechanisms in the tumor microenvironment (TME), including limited local immune...