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Primary Target

PDZ-binding kinase

2

Histamine H1 receptor

316

Dopamine D2 receptor

311

DNA

282

Serotonin 2a (5-HT2a) receptor

237

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Possibly Marketed Outside US

2

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Approved

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Approval Year

Unknown

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Condition

Colon cancer

2

Gastroesophageal reflux disease

2

Peptic ulcer

2

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Treatment Modality

Primary

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Originator

Ilyang Pharmaceutical

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Chemical

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CAS

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FDA UNII

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PUBCHEM

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SMS_ID

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ChEMBL

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Principal Form

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ILAPRAZOLE

776Q6XX45J

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

PDZ-binding kinase

Sodium/potassium-transporting ATPase

Conditions:

Gastroesophageal reflux disease

Ilaprazole or IY-81149 (2-[(4-methoxy-3-methyl)-2-pyridinyl]methylsulfinyl -5-(1H-pyrrol-1-yl)-1H-benzimidazole, CAS 172152-36-2) is a proton pump inhibitor. Ilaprazole revealed the characteristics as a strong proton pump inhibitor, and its potency ...

against gastric acid secretion was superior to that of the reference drug, omeprazole. Ilaprazole is approved in China and South Korea for the treatment of gastroesophageal reflux disorders (GERD), dyspepsia and peptic ulcers. Recently it was discovered that ilaprazole inhibited the cancer growth by targeting T-cell-originated protein kinase (TOPK) both in vitro and in vivo.

Ilaprazole sodium

T8KRT8S6GR

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

PDZ-binding kinase

Sodium/potassium-transporting ATPase

Conditions:

Gastroesophageal reflux disease

Ilaprazole or IY-81149 (2-[(4-methoxy-3-methyl)-2-pyridinyl]methylsulfinyl -5-(1H-pyrrol-1-yl)-1H-benzimidazole, CAS 172152-36-2) is a proton pump inhibitor. Ilaprazole revealed the characteristics as a strong proton pump inhibitor, and its potency ...

against gastric acid secretion was superior to that of the reference drug, omeprazole. Ilaprazole is approved in China and South Korea for the treatment of gastroesophageal reflux disorders (GERD), dyspepsia and peptic ulcers. Recently it was discovered that ilaprazole inhibited the cancer growth by targeting T-cell-originated protein kinase (TOPK) both in vitro and in vivo.

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