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P2X purinoceptor 2

6

Histamine H1 receptor

316

Dopamine D2 receptor

311

DNA

282

Serotonin 2a (5-HT2a) receptor

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Metabolic syndrome

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Tardive dyskinesia

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Type 2 diabetes mellitus

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Epiretinal membrane surgery

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Gale, E.F.|Epps, H.M.R.

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Mihalik, B.

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Chemical

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Other lipid modifying agents

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Showing 1 - 6 of 6 results

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BRILLIANT BLUE G

M1ZRX790SI

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Status:

US Approved Rx (2019)

First approved in 2018

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

P2X purinoceptor 4

P2X purinoceptor 2

P2X purinoceptor 7

Conditions:

Macular surgery

Epiretinal membrane surgery

Brilliant Blue G is triphenylmethane dye that was developed for use in the textile industry but is now commonly used for staining proteins in analytical biochemistry. The Bradford assay is a standard, rapid dye-binding assay that uses Brilliant Blue ...

G to quantify the amount of protein in a solution. Brilliant Blue G also acts as a selective inhibitor of the P2X purinoceptor channel P2X7 (IC50s = 10.1 and 265 nM for rat and human P2X7, respectively). In mice, it inhibits interleukin-1β expression and reduces neurological injury secondary to traumatic brain injury. Brilliant Blue G was used to prepare the protein reagent for the determination of protein content of the collagenase enzyme isolated from fish waste. It may be employed as a stain for the internal limiting membrane (ILM) for the macular hole (MH) and epiretinal membrane (ERM) surgery.

PYRIDOXAL PHOSPHATE ANHYDROUS

F06SGE49M6

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Status:

Possibly Marketed Outside US

First approved in 2011

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

P2X purinoceptor 1

P2X purinoceptor 2

P2X purinoceptor 1

Conditions:

Tardive dyskinesia

Metabolic syndrome

Type 2 diabetes mellitus

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P) is a coenzyme, the active form of vitamin B6. Pyridoxal 5′-phosphate (PLP) is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase...

(CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates. PLP acts as a coenzyme in all transamination reactions, in various beta-elimination reactions, in the condensation reaction in heme synthesis.

PYRIDOXAL CALCIUM PHOSPHATE ANHYDROUS

1JJ4V52LB5

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Status:

Possibly Marketed Outside US

First approved in 2011

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

P2X purinoceptor 1

P2X purinoceptor 2

P2X purinoceptor 1

Conditions:

Tardive dyskinesia

Metabolic syndrome

Type 2 diabetes mellitus

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P) is a coenzyme, the active form of vitamin B6. Pyridoxal 5′-phosphate (PLP) is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase...

(CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates. PLP acts as a coenzyme in all transamination reactions, in various beta-elimination reactions, in the condensation reaction in heme synthesis.

PYRIDOXAL CALCIUM PHOSPHATE TRIHYDRATE

J766QN40UD

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Status:

Possibly Marketed Outside US

First approved in 2011

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

P2X purinoceptor 1

P2X purinoceptor 2

P2X purinoceptor 1

Conditions:

Tardive dyskinesia

Metabolic syndrome

Type 2 diabetes mellitus

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P) is a coenzyme, the active form of vitamin B6. Pyridoxal 5′-phosphate (PLP) is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase...

(CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates. PLP acts as a coenzyme in all transamination reactions, in various beta-elimination reactions, in the condensation reaction in heme synthesis.

PYRIDOXAL PHOSPHATE

5V5IOJ8338

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Status:

Possibly Marketed Outside US

First approved in 2011

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

P2X purinoceptor 1

P2X purinoceptor 2

P2X purinoceptor 1

Conditions:

Tardive dyskinesia

Metabolic syndrome

Type 2 diabetes mellitus

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P) is a coenzyme, the active form of vitamin B6. Pyridoxal 5′-phosphate (PLP) is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase...

(CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates. PLP acts as a coenzyme in all transamination reactions, in various beta-elimination reactions, in the condensation reaction in heme synthesis.

PYRIDOXAL PHOSPHATE DISODIUM

ERZ74D7E6J

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Status:

Possibly Marketed Outside US

First approved in 2011

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

P2X purinoceptor 1

P2X purinoceptor 2

P2X purinoceptor 1

Conditions:

Tardive dyskinesia

Metabolic syndrome

Type 2 diabetes mellitus

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P) is a coenzyme, the active form of vitamin B6. Pyridoxal 5′-phosphate (PLP) is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase...

(CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates. PLP acts as a coenzyme in all transamination reactions, in various beta-elimination reactions, in the condensation reaction in heme synthesis.

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