U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)



2,4-Diamino-6-hydroxypyrimidine is a selective, specific inhibitor of GTP cyclohydrolase I, a rate-limiting enzyme for the de novo biosynthesis of biopterin. Experiments in rats have shown that 4-Diamino-6-hydroxypyrimidine possesses protective effects against postburn Staphylococcus aureus sepsis.