Showing 1 - 8 of 8 results
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Abiraterone acetate (trade name Zytiga) is a prodrug to the abiraterone, steroidal compound with antiandrogen activity and a 17 α-hydroxylase/C17,20-lyase (CYP17) inhibitor. It is indicated in combination with prednisone for the treatment of patients...
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Ketoconazole is an azole antifungal. Ketoconazole was the first broad-spectrum oral antifungal agent available to treat systemic and superficial mycoses. Evidence of hepatotoxicity associated with its use emerged within the first few years of its app...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Seviteronel (VT-464) is a 17,20-lyase selective inhibitor of CYP17A1, which plays key roles in adrenal and intratumoral de novo biosynthesis of androgens. The inhibition of 17,20-lyase activity by seviteronel (VT-464) is enough to reduce androgen lev...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Galeterone (TOK-001, formerly called VN/124-1) is a potent anti-androgen with three modes of action. The compound acts as a specific androgen receptor antagonist, inhibits CYP17 lyase while conserving CYP17 hydroxylase function, and decreases overall...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Orteronel (TAK-700) is a non-steroidal antiandrogen, discovered by Takeda Pharmaceutical Company Limited, that selectively inhibits the 17,20 lyase enzyme (CYP17A1). This enzyme, which is present in both the testes and adrenal glands, is central to t...
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Mono(ethylhexyl) phthalate (MEHP) is an active metabolite of Bis(2-ethylhexyl)phthalate (DEHP). DEHP is a widely used plasticizer. MEHP has been shown to be moderately toxic. Studies involving orally administered MEHP revealed the mild hepatic change...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Abiraterone acetate (trade name Zytiga) is a prodrug to the abiraterone, steroidal compound with antiandrogen activity and a 17 α-hydroxylase/C17,20-lyase (CYP17) inhibitor. It is indicated in combination with prednisone for the treatment of patients...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Ketoconazole is an azole antifungal. Ketoconazole was the first broad-spectrum oral antifungal agent available to treat systemic and superficial mycoses. Evidence of hepatotoxicity associated with its use emerged within the first few years of its app...