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Primary Target

Carnitine O-palmitoyltransferase 2, mitochondrial

13

Histamine H1 receptor

315

Dopamine D2 receptor

297

DNA

278

Bacterial penicillin-binding protein

233

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Development Status

US Approved Rx

13

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Highest Phase

Approved

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Approval Year

1985

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Condition

Congestive heart failure

13

Peripheral arterial occlusive disorders

13

Systemic primary carnitine deficiency

13

Ulcerative colitis

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Treatment Modality

Primary

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CNS Activity

CNS Penetrant

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Originator

Sigma-Tau

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Substance Class

Chemical

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Code System

FDA UNII

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PUBCHEM

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CAS

12

SMS_ID

9

EPA CompTox

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

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NERVOUS SYSTEM

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ATC Level 2

OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS

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PSYCHOANALEPTICS

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ATC Level 3

OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS

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PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS

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ATC Level 4

Amino acids and derivatives

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Other psychostimulants and nootropics

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Substance Form

Salts, Hydrates, Esters, etc.

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Principal Form

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Showing 11 - 13 of 13 results

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LEVOCARNITINE TARTRATE

4D8F2Q45LQ

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Status:

US Approved Rx (2021)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

LEVACECARNINE HYDROCHLORIDE

NDW10MX58T

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Status:

US Approved Rx (2021)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

ACETYLCARNITINE

6DH1W9VH8Q

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Status:

US Approved Rx (2021)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

Showing 11 - 13 of 13 results

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