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Primary Target

Carnitine O-acetyltransferase

18

Histamine H1 receptor

315

Dopamine D2 receptor

297

DNA

278

Bacterial penicillin-binding protein

233

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US Approved Rx

13

Other

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Approved

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Not Provided

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Approval Year

1985

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Unknown

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Condition

Congestive heart failure

13

Peripheral arterial occlusive disorders

13

Systemic primary carnitine deficiency

13

Ulcerative colitis

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Unknown

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Treatment Modality

Primary

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Preventing

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CNS Activity

CNS Penetrant

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Originator

Sigma-Tau

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Reimer, W.

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Kyorin Pharmaceutical

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Chemical

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Code System

FDA UNII

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PUBCHEM

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CAS

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EPA CompTox

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SMS_ID

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OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS

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PSYCHOANALEPTICS

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OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS

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PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS

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ATC Level 4

Amino acids and derivatives

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Other psychostimulants and nootropics

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Salts, Hydrates, Esters, etc.

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Showing 1 - 10 of 18 results

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LEVOCARNITINE

0G389FZZ9M

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Status:

US Approved Rx (1985)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

ERUCIC ACID

075441GMF2

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Carnitine O-acetyltransferase

Conditions:

X-linked adrenoleukodystrophy

Brassidic acid (22 carbon atoms) was first prepared from erucic acid by Reimer W. in 1886. It is a monounsaturated (one trans (E) double bond; shorthand nomenclature cannot be used to name trans fatty acids) fatty acid member of the sub-group called ...

very long chain fatty acids (VLCFA), from 20 carbon atoms onwards, and is the trans-isomer of erucic acid. At a concentration of 0.1 mM, brassidic acid produced small increases in palmitoyl-CoA oxidation and carnitine acetyltransferase activities in hepatocytes cultured 70 hr.

NICOMOL

215U8X2R44

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Carnitine O-acetyltransferase

D-amino-acid oxidase

Cholesterol biosynthesis

Conditions:

Limb arterial occlusive disease

Raynaud syndrome

Hypolipidemic agent, Nicomol is an ingredient of Cholexamin in Japan. Cholexamin, a lipid metabolism and peripheral circulation improving agent, was launched by KYORIN Pharmaceutical in 1971. It is indicated for the treatment of hyperlipemia, improve...

ment in peripheral circulatory disorder resulting from the following diseases Chilblain, limb arterial occlusive disease (obstructive thromboarteritis and arteriosclerosis obliterans), Raynaud syndrome.

LEVOCARNITINE FUMARATE

8Q37GK439O

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Status:

US Approved Rx (1985)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

ACETYL-L-CARNITINE ARGINATE DIHYDROCHLORIDE

DDL9STT4CE

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Status:

US Approved Rx (1985)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

GLYCINE PROPIONYL-L-CARNITINE HYDROCHLORIDE

LY38SJU4DG

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Status:

US Approved Rx (1985)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

GLYCINE PROPIONYL-L-CARNITINE

8KVN59D5FL

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Status:

US Approved Rx (1985)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

ACETYL-L-CARNITINE ARGINATE

PIY2W03CO6

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Status:

US Approved Rx (1985)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

LEVOCARNITINE MONOTARTRATE

4OCB0F120X

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Status:

US Approved Rx (1985)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

LEVOCARNITINE PROPIONATE

0HU2UI27HF

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Status:

US Approved Rx (1985)

First approved in 1985

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial carnitine/acylcarnitine carrier protein

Carnitine O-acetyltransferase

Carnitine O-palmitoyltransferase 1, liver isoform

Oxidative phosphorylation

Carnitine O-palmitoyltransferase 1, muscle isoform

Oxidative Stress

Conditions:

Systemic primary carnitine deficiency

Ulcerative colitis

Peripheral arterial occlusive disorders

Congestive heart failure

Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activit...

y. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.

Showing 1 - 10 of 18 results

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