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ATP-binding cassette sub-family C member 8

3

Histamine H1 receptor

315

Dopamine D2 receptor

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Bacterial penicillin-binding protein

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Showing 1 - 3 of 3 results

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PROTOPINE

UIW569HT35

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

ATP-binding cassette sub-family C member 8

Beta-2 adrenergic receptor

Conditions:

Protopine is the isoquinoline alkaloid found primarily in the plant families Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae. It has diverse biological activities, such as anti-thrombotic, anti-inflammatory, anti-parasitic activity, antimicrobial...

activity, as well as hepatoprotective effects in animal models. The biological activities of protopine are associated with its ability selectively inhibits K(ATP) channels by targeting on SUR1 subunit. In addition, was discovered that β2 -adrenoceptor (β2 -AR) is a target for antiasthma activities of protopine. On this target, binding of the drug occurs on the amino acid residual of Ser 169 through the formation of hydrogen bonds and receptor‐drug bumps.

GLICLAZIDE

G4PX8C4HKV

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

potassium inwardly rectifying channel, subfamily J, member 11

ATP-binding cassette sub-family C member 8

Conditions:

Type 2 diabetes mellitus

Gliclazide (BILXONA®) is an oral sulfonylurea hypoglycemic agent which is used in type 2 diabetes to stimulate insulin production. It differs from other related compounds by an N-containing heterocyclic ring with an endocyclic bond. Gliclazide (BILXO...

NA®) reduces blood glucose levels by stimulating insulin secretion from the beta-cells of the islets of Langerhans. Increase in postprandial insulin and C-peptide secretion persists after two years of treatment. In addition to these metabolic properties, Gliclazide (BILXONA®) has haemovascular properties. It is not available for sale in the United States.

PROTOPINE HYDROCHLORIDE

96481YJ70G

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

ATP-binding cassette sub-family C member 8

Beta-2 adrenergic receptor

Conditions:

Protopine is the isoquinoline alkaloid found primarily in the plant families Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae. It has diverse biological activities, such as anti-thrombotic, anti-inflammatory, anti-parasitic activity, antimicrobial...

activity, as well as hepatoprotective effects in animal models. The biological activities of protopine are associated with its ability selectively inhibits K(ATP) channels by targeting on SUR1 subunit. In addition, was discovered that β2 -adrenoceptor (β2 -AR) is a target for antiasthma activities of protopine. On this target, binding of the drug occurs on the amino acid residual of Ser 169 through the formation of hydrogen bonds and receptor‐drug bumps.

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