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Class (Stereo):
CHEMICAL (ABSOLUTE)
Marimastat is a broad spectrum matrix metalloprotease (MMP) inhibitor. It is an angiogenesis and metastasis inhibitor. It mimics the peptide structure of natural MMP substrates and binds to matrix metalloproteases, thereby preventing the degradation ...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Aderbasib, also known as INCB007839, is an orally bioavailable low nanomolar hydroxamate-based inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbas...
TAPI-1, known in the earlier literature as just TAPI, is an inhibitor of tumor necrosis factor-alpha converting enzyme (TACE)/ADAM 17, that inhibits the cleavage of TNF-α, TNFRI (p60), and TNFRII (p80). It was shown on mice model, that administration...