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Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
BIX-02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. Intrathecal injection of BIX-02188, a novel specific i...