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Development Status

US Previously Marketed

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Primary Target

Acetylcholinesterase

4

Muscle-type nicotinic acetylcholine receptor

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Highest Phase

Approved

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Approval Year

1950

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Condition

Muscle spasm

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Treatment Modality

Preventing

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CNS Activity

CNS Penetrant

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Originator

Barlow, R.B.|Ing, H.R.|Paton, W.D.M.|Zaimis, E.J.

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Substance Class

Chemical

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Code System

CAS

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EPA CompTox

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FDA UNII

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PUBCHEM

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EVMPD

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Substance Form

Salts, Hydrates, Esters, etc.

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Principal Form

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Showing 1 - 4 of 4 results

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DECAMETHONIUM

C1CG1S3T2W

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Status:

US Previously Marketed

First approved in 1950

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acetylcholinesterase

Muscle-type nicotinic acetylcholine receptor

Conditions:

Decamethylene disquaternary salts, with a ten-carbon (C10) chain between the quaternary groups, had the most potent curariform action in the series of polymethylene bisquaternaries. Decamethonium was used clinically as a neuromuscular blocking drug f...

or a short time. Decamethonium was different from d-tubocurarine and that it produced a transient augmentation of contraction. C10 produces neuromuscular block by initiating some active response in the endplate or muscle fibre. Unlike d-tubocurare, decamethonium was not reversed by anticholinesterase agents.

DECAMETHONIUM CHLORIDE

62I07N48KG

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Status:

US Previously Marketed

First approved in 1950

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acetylcholinesterase

Muscle-type nicotinic acetylcholine receptor

Conditions:

Decamethylene disquaternary salts, with a ten-carbon (C10) chain between the quaternary groups, had the most potent curariform action in the series of polymethylene bisquaternaries. Decamethonium was used clinically as a neuromuscular blocking drug f...

or a short time. Decamethonium was different from d-tubocurarine and that it produced a transient augmentation of contraction. C10 produces neuromuscular block by initiating some active response in the endplate or muscle fibre. Unlike d-tubocurare, decamethonium was not reversed by anticholinesterase agents.

DECAMETHONIUM IODIDE

TX886PAQ89

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Status:

US Previously Marketed

First approved in 1950

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acetylcholinesterase

Muscle-type nicotinic acetylcholine receptor

Conditions:

Decamethylene disquaternary salts, with a ten-carbon (C10) chain between the quaternary groups, had the most potent curariform action in the series of polymethylene bisquaternaries. Decamethonium was used clinically as a neuromuscular blocking drug f...

or a short time. Decamethonium was different from d-tubocurarine and that it produced a transient augmentation of contraction. C10 produces neuromuscular block by initiating some active response in the endplate or muscle fibre. Unlike d-tubocurare, decamethonium was not reversed by anticholinesterase agents.

DECAMETHONIUM BROMIDE

55C6RK944K

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Status:

US Previously Marketed

First approved in 1950

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Acetylcholinesterase

Muscle-type nicotinic acetylcholine receptor

Conditions:

Decamethylene disquaternary salts, with a ten-carbon (C10) chain between the quaternary groups, had the most potent curariform action in the series of polymethylene bisquaternaries. Decamethonium was used clinically as a neuromuscular blocking drug f...

or a short time. Decamethonium was different from d-tubocurarine and that it produced a transient augmentation of contraction. C10 produces neuromuscular block by initiating some active response in the endplate or muscle fibre. Unlike d-tubocurare, decamethonium was not reversed by anticholinesterase agents.

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