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US Previously Marketed

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Primary Target

Solute carrier organic anion transporter family member 1B1

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Solute carrier organic anion transporter family member 1B3

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Approval Year

1921

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Condition

Labor complications

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Treatment Modality

Primary

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Originator

Dobbie, J.J.|Lauder, A.|Tinkler, C.K.

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HYDRASTININE

V1I0L48X6E

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Solute carrier organic anion transporter family member 1B1

Solute carrier organic anion transporter family member 1B3

Conditions:

Labor complications

Hydrastinine is a synthetic alkaloid prepared by various processes from either hydrastine, berberine, or narcotine. It exerts a strong stimulating action on the uterus of all species studied, including human. Hydrastinine and the closely related alka...

loid cotarnine have been employed as hemostatics, particularly in abnormal uterine conditions. In the non-pregnant animal, hydrastinine in doses of 10 mg. depressed both tonus and activity, even after the section of the hypogastric. In the pregnant cat, it caused the uterus to contract. A stimulant action was also noted in the non-pregnant animal if nicotine were administered prior to hydrastinine. The rabbit uterus in situ was strongly contracted. Laidlaw believed that hydrastinine acted on the uterus both directly on the smooth muscle and also through its sympathetic innervation. Repeated administration of large doses for a period of time resulted in greatly increased amplitude of contractions which persisted after removal of the drug. The drug was patented by Bayer as a haemostatic drug during the 1910s.

HYDRASTININE HYDROCHLORIDE

S8253P6A1G

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Solute carrier organic anion transporter family member 1B1

Solute carrier organic anion transporter family member 1B3

Conditions:

Labor complications

Hydrastinine is a synthetic alkaloid prepared by various processes from either hydrastine, berberine, or narcotine. It exerts a strong stimulating action on the uterus of all species studied, including human. Hydrastinine and the closely related alka...

loid cotarnine have been employed as hemostatics, particularly in abnormal uterine conditions. In the non-pregnant animal, hydrastinine in doses of 10 mg. depressed both tonus and activity, even after the section of the hypogastric. In the pregnant cat, it caused the uterus to contract. A stimulant action was also noted in the non-pregnant animal if nicotine were administered prior to hydrastinine. The rabbit uterus in situ was strongly contracted. Laidlaw believed that hydrastinine acted on the uterus both directly on the smooth muscle and also through its sympathetic innervation. Repeated administration of large doses for a period of time resulted in greatly increased amplitude of contractions which persisted after removal of the drug. The drug was patented by Bayer as a haemostatic drug during the 1910s.

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