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Development Status

US Approved Rx

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Primary Target

Cytochrome P450 51

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Highest Phase

Approved

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Approval Year

1985

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Condition

Vulvovaginal candidiasis

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Curative

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Chemical

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Code System

CAS

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CHEBI

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ChEMBL

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DAILYMED

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DRUG BANK

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ATC Level 1

GENITO URINARY SYSTEM AND SEX HORMONES

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ATC Level 2

GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS

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ATC Level 3

ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS

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ATC Level 4

Imidazole derivatives

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Salts, Hydrates, Esters, etc.

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BUTOCONAZOLE

0Q771797PH

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Status:

US Approved Rx (2012)

First approved in 1985

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Cytochrome P450 51

Conditions:

Vulvovaginal candidiasis

Butoconazole, trade names Gynazole-1, an imidazole antifungal used in gynecology for the local treatment of vulvovaginal candidiasis (infections caused by Candida). The exact mechanism of the antifungal action of butoconazole nitrate is unknown; howe...

ver, it is presumed to function as other imidazole derivatives via inhibition of steroid synthesis. Imidazoles generally inhibit the conversion of lanosterol to ergosterol, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell.

BUTOCONAZOLE NITRATE

4805237NP5

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Status:

US Approved Rx (2012)

First approved in 1985

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Cytochrome P450 51

Conditions:

Vulvovaginal candidiasis

Butoconazole, trade names Gynazole-1, an imidazole antifungal used in gynecology for the local treatment of vulvovaginal candidiasis (infections caused by Candida). The exact mechanism of the antifungal action of butoconazole nitrate is unknown; howe...

ver, it is presumed to function as other imidazole derivatives via inhibition of steroid synthesis. Imidazoles generally inhibit the conversion of lanosterol to ergosterol, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell.

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