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US Previously Marketed

7

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Primary Target

Taste receptor type 2 member 10

7

Taste receptor type 2 member 13

7

Taste receptor type 2 member 4

7

Taste receptor type 2 member 8

7

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Approval Year

1962

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Condition

Unknown

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Originator

Macfarlan Smith

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Substance Class

Chemical

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Code System

FDA UNII

7

PUBCHEM

7

CAS

6

EPA CompTox

5

DAILYMED

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Substance Form

Salts, Hydrates, Esters, etc.

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Showing 1 - 7 of 7 results

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DENATONIUM

4IK22DF4OU

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Status:

US Previously Marketed

First approved in 1962

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Taste receptor type 2 member 10

Taste receptor type 2 member 8

Taste receptor type 2 member 4

Taste receptor type 2 member 13

Conditions:

Denatonium, usually available as denatonium benzoate (trade names Bitrex) is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Scientists at Macfarlan Smith, Ltd. of Edin...

burgh, Scotland discovered Bitrex during research on derivatives of the anesthetic lidocaine. The extremely bitter taste proved effective in reducing ingestion by humans and animals. Denatonium is commonly included in placebo medications used in clinical trials to match the bitter taste of certain medications. Denatonium activates bitter taste receptor, mainly, TAS2R4, TAS2R8, TAS2R10, TAS2R13 on many cell types and plays important roles in chemical release, ciliary beating and smooth muscle relaxation through intracellular Ca(2+)-dependent pathways.

DENATONIUM SACCHARIDE

G2NT7SMW7M

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Status:

US Previously Marketed

First approved in 1962

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Taste receptor type 2 member 10

Taste receptor type 2 member 8

Taste receptor type 2 member 4

Taste receptor type 2 member 13

Conditions:

Denatonium, usually available as denatonium benzoate (trade names Bitrex) is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Scientists at Macfarlan Smith, Ltd. of Edin...

burgh, Scotland discovered Bitrex during research on derivatives of the anesthetic lidocaine. The extremely bitter taste proved effective in reducing ingestion by humans and animals. Denatonium is commonly included in placebo medications used in clinical trials to match the bitter taste of certain medications. Denatonium activates bitter taste receptor, mainly, TAS2R4, TAS2R8, TAS2R10, TAS2R13 on many cell types and plays important roles in chemical release, ciliary beating and smooth muscle relaxation through intracellular Ca(2+)-dependent pathways.

DENATONIUM ACETATE

8QG4DAT7RW

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Status:

US Previously Marketed

First approved in 1962

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Taste receptor type 2 member 10

Taste receptor type 2 member 8

Taste receptor type 2 member 4

Taste receptor type 2 member 13

Conditions:

Denatonium, usually available as denatonium benzoate (trade names Bitrex) is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Scientists at Macfarlan Smith, Ltd. of Edin...

burgh, Scotland discovered Bitrex during research on derivatives of the anesthetic lidocaine. The extremely bitter taste proved effective in reducing ingestion by humans and animals. Denatonium is commonly included in placebo medications used in clinical trials to match the bitter taste of certain medications. Denatonium activates bitter taste receptor, mainly, TAS2R4, TAS2R8, TAS2R10, TAS2R13 on many cell types and plays important roles in chemical release, ciliary beating and smooth muscle relaxation through intracellular Ca(2+)-dependent pathways.

DENATONIUM ACETATE MONOHYDRATE

YE84H43CRF

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Status:

US Previously Marketed

First approved in 1962

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Taste receptor type 2 member 10

Taste receptor type 2 member 8

Taste receptor type 2 member 4

Taste receptor type 2 member 13

Conditions:

Denatonium, usually available as denatonium benzoate (trade names Bitrex) is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Scientists at Macfarlan Smith, Ltd. of Edin...

burgh, Scotland discovered Bitrex during research on derivatives of the anesthetic lidocaine. The extremely bitter taste proved effective in reducing ingestion by humans and animals. Denatonium is commonly included in placebo medications used in clinical trials to match the bitter taste of certain medications. Denatonium activates bitter taste receptor, mainly, TAS2R4, TAS2R8, TAS2R10, TAS2R13 on many cell types and plays important roles in chemical release, ciliary beating and smooth muscle relaxation through intracellular Ca(2+)-dependent pathways.

DENATONIUM CHLORIDE

0W5171805N

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Status:

US Previously Marketed

First approved in 1962

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Taste receptor type 2 member 10

Taste receptor type 2 member 8

Taste receptor type 2 member 4

Taste receptor type 2 member 13

Conditions:

Denatonium, usually available as denatonium benzoate (trade names Bitrex) is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Scientists at Macfarlan Smith, Ltd. of Edin...

burgh, Scotland discovered Bitrex during research on derivatives of the anesthetic lidocaine. The extremely bitter taste proved effective in reducing ingestion by humans and animals. Denatonium is commonly included in placebo medications used in clinical trials to match the bitter taste of certain medications. Denatonium activates bitter taste receptor, mainly, TAS2R4, TAS2R8, TAS2R10, TAS2R13 on many cell types and plays important roles in chemical release, ciliary beating and smooth muscle relaxation through intracellular Ca(2+)-dependent pathways.

DENATONIUM BENZOATE ANHYDROUS

M5BA6GAF1O

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Status:

US Previously Marketed

First approved in 1962

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Taste receptor type 2 member 10

Taste receptor type 2 member 8

Taste receptor type 2 member 4

Taste receptor type 2 member 13

Conditions:

Denatonium, usually available as denatonium benzoate (trade names Bitrex) is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Scientists at Macfarlan Smith, Ltd. of Edin...

burgh, Scotland discovered Bitrex during research on derivatives of the anesthetic lidocaine. The extremely bitter taste proved effective in reducing ingestion by humans and animals. Denatonium is commonly included in placebo medications used in clinical trials to match the bitter taste of certain medications. Denatonium activates bitter taste receptor, mainly, TAS2R4, TAS2R8, TAS2R10, TAS2R13 on many cell types and plays important roles in chemical release, ciliary beating and smooth muscle relaxation through intracellular Ca(2+)-dependent pathways.

DENATONIUM BENZOATE

4YK5Z54AT2

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Status:

US Previously Marketed

First approved in 1962

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Taste receptor type 2 member 10

Taste receptor type 2 member 8

Taste receptor type 2 member 4

Taste receptor type 2 member 13

Conditions:

Denatonium, usually available as denatonium benzoate (trade names Bitrex) is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Scientists at Macfarlan Smith, Ltd. of Edin...

burgh, Scotland discovered Bitrex during research on derivatives of the anesthetic lidocaine. The extremely bitter taste proved effective in reducing ingestion by humans and animals. Denatonium is commonly included in placebo medications used in clinical trials to match the bitter taste of certain medications. Denatonium activates bitter taste receptor, mainly, TAS2R4, TAS2R8, TAS2R10, TAS2R13 on many cell types and plays important roles in chemical release, ciliary beating and smooth muscle relaxation through intracellular Ca(2+)-dependent pathways.

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