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Primary Target

Canalicular multispecific organic anion transporter 1

2

Solute carrier organic anion transporter family member 1B1

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aldo-keto reductase family 1, member C20

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glutathione S-transferase, Oesophagostomum dentatum

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Liver disease

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Diagnostic

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Originator

Rosenthal, S.M.|White, E.C.

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CHEBI

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EPA CompTox

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EVMPD

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Tests for liver functional capacity

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SULFOBROMOPHTHALEIN

0C2P5QKL36

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Canalicular multispecific organic anion transporter 1

Solute carrier organic anion transporter family member 1B1

aldo-keto reductase family 1, member C20

glutathione S-transferase, Oesophagostomum dentatum

Conditions:

Sulfobromophthalein (BSP) is a dye with a high affinity for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after...

conjugation to glutathione, is excreted into bile by Mrp2.3 It was found to inhibit the aldo-keto reductase ARK1C20. Sulfobromophthalein (BSP) is used in diagnosis of hepatic disorders.It is also used for the quantitative determination of proteins.

SULFOBROMOPHTHALEIN SODIUM

62E5JU30OV

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Canalicular multispecific organic anion transporter 1

Solute carrier organic anion transporter family member 1B1

aldo-keto reductase family 1, member C20

glutathione S-transferase, Oesophagostomum dentatum

Conditions:

Sulfobromophthalein (BSP) is a dye with a high affinity for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after...

conjugation to glutathione, is excreted into bile by Mrp2.3 It was found to inhibit the aldo-keto reductase ARK1C20. Sulfobromophthalein (BSP) is used in diagnosis of hepatic disorders.It is also used for the quantitative determination of proteins.

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