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Nociceptin receptor

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Anxiety

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Pfizer

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MCOPPB

8NMK0UG3HV

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Nociceptin receptor

Conditions:

MCOPPB trihydrochloride (MCOPPB) is a nonpeptide agonist of the NOP receptor, an anxiolytic agent. MCOPPB has a high affinity for the human NOP receptor (pKi = 10.07 +/- 0.01) and selectivity for the NOP receptor over other members of the opioid rece...

ptor family: 12-, 270- and >1000-fold more selective for the NOP receptor than for the micro-, kappa-, and delta-receptor, respectively. In an ex vivo binding study, MCOPPB (10 mg/kg, p.o.) inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. MCOPPB - a compound with few adverse effects on the central nervous system - is a potential therapeutic agent for the treatment of anxiety.

MCOPPB TRIHYDROCHLORIDE

SIO8DBP4K7

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Nociceptin receptor

Conditions:

MCOPPB trihydrochloride (MCOPPB) is a nonpeptide agonist of the NOP receptor, an anxiolytic agent. MCOPPB has a high affinity for the human NOP receptor (pKi = 10.07 +/- 0.01) and selectivity for the NOP receptor over other members of the opioid rece...

ptor family: 12-, 270- and >1000-fold more selective for the NOP receptor than for the micro-, kappa-, and delta-receptor, respectively. In an ex vivo binding study, MCOPPB (10 mg/kg, p.o.) inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. MCOPPB - a compound with few adverse effects on the central nervous system - is a potential therapeutic agent for the treatment of anxiety.

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