WAY-213613 to be a potent, EAAT2-preferring, competitive nonsubstrate inhibitor of EAAT2. WAY-213613 was devoid of either agonist or antagonist activity at the ionotropic NMDA and AMPA receptors expressed natively in cultured hippocampal neurons, or at the human mGlu receptors 1, 2, and 4 heterologously expressed in stable cell lines. It is used in scientific research into the function of the glutamate transporters.