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Development Status

US Previously Marketed

12

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Primary Target

Hydroxyapatite

12

Interleukin-1 beta

12

Ribonucleoside-diphosphate reductase RR1

12

Serotransferrin

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Highest Phase

Approved

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Approval Year

1991

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Condition

Cancer-related hypercalcemia

12

Non-Hodgkin's lymphoma

12

Relapsed or refractory lymphoma

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Treatment Modality

Primary

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CNS Penetrant

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Chemical

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FDA UNII

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PUBCHEM

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EPA CompTox

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MERCK INDEX

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Salts, Hydrates, Esters, etc.

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GALLIUM CATION

F7K5MP217W

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

GALLIUM DICITRATE

6ZNH95J8XB

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

AMMONIUM HEXAFLUOROGALLATE

4X2AHU48WW

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

GALLIUM OXIDE

46F059V66A

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

GALLIUM NITRIDE (GAN)

1R9CC3P9VL

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

GALLIUM(III) HYDROXIDE

S3PJW60NUM

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

GALLIUM CITRATE

HT6C49L0ZP

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

GALLIUM TRIFLUORIDE

3EG50JLZ49

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

GALLIUM TRIFLUORIDE TRIHYDRATE

U3D052656Y

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

GALLIUM CHLORIDE

4Y6GQD4915

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Status:

US Previously Marketed

First approved in 1991

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Ribonucleoside-diphosphate reductase RR1

Serotransferrin

Ribonucleoside-diphosphate reductase RR1

Interleukin-1 beta

Conditions:

Non-Hodgkin's lymphoma

Relapsed or refractory lymphoma

Cancer-related hypercalcemia

Gallium nitrate (brand name Ganite) is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. Ganite exerts a hypocalcemic effect by inhibiting calcium resorption from bone, possibly by reducing increased bone turnover. It was...

shown, that gallium favorably altered the mineral properties to enhance hydroxyapatite crystallization and reduced mineral solubility. The drug also acted on the cellular components of bone to reduce bone resorption by decreasing acid secretion by osteoclasts. Nevertheless, ganite was withdrawn from sale, although the reasons was not the safety or effectiveness. Gallium nitrate inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. Gallium binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. In phase II of clinical trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

Showing 1 - 10 of 12 results

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