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Development Status

Investigational

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Primary Target

Cytochrome P450 3A4

2

DNA

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DNA topoisomerase I

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DNA topoisomerase II

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Highest Phase

Phase II

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Approval Year

Unknown

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Condition

Hepatocellular carcinoma

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Treatment Modality

Primary

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Originator

Farmitalia CarloErba Research Center

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Chemical

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CAS

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PUBCHEM

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Salts, Hydrates, Esters, etc.

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NEMORUBICIN

7618O47BQM

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase I

DNA topoisomerase II

Cytochrome P450 3A4

Conditions:

Hepatocellular carcinoma

Nemorubicin, a doxorubicin derivative, is a DNA-intercalator, topoisomerase and RNA synthesis inhibitor that was undergoing development with Nerviano Medical Sciences (Nerviano MS; formerly Pharmacia Italia) for the treatment of solid tumours, specif...

ically, the loco-regional treatment of primary liver tumours (hepatocellular carcinoma). The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway, where current therapies fail. Nemorubicin is biotransformed in the liver into cytotoxic metabolites that may further contribute to render this drug highly active against primary liver tumors or liver metastases. Clinical trials were conducted in Europe, US and China with Nemorubicin given at different dose-schedules and by different routes of administration: as single agent by systemic IV route, oral route and by intra-hepatic artery (IHA) infusion alone or in combination with cisplatin.

NEMORUBICIN HYDROCHLORIDE

2Q6F8JYX76

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Search for Structure

Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase I

DNA topoisomerase II

Cytochrome P450 3A4

Conditions:

Hepatocellular carcinoma

Nemorubicin, a doxorubicin derivative, is a DNA-intercalator, topoisomerase and RNA synthesis inhibitor that was undergoing development with Nerviano Medical Sciences (Nerviano MS; formerly Pharmacia Italia) for the treatment of solid tumours, specif...

ically, the loco-regional treatment of primary liver tumours (hepatocellular carcinoma). The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway, where current therapies fail. Nemorubicin is biotransformed in the liver into cytotoxic metabolites that may further contribute to render this drug highly active against primary liver tumors or liver metastases. Clinical trials were conducted in Europe, US and China with Nemorubicin given at different dose-schedules and by different routes of administration: as single agent by systemic IV route, oral route and by intra-hepatic artery (IHA) infusion alone or in combination with cisplatin.

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