NS3623 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator. It was shown that treatment of transgenic mouse model of sickle cell disease (SAD mice) with NS3623 improves erythrocyte hydration and diminishes sickling, probably by lowering of the Cl-conductance, which limits salt and concomitant water loss mediated by the Gardós channel, that makes NS3623 antisickling agent in vivo