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Development Status

US Previously Marketed

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Primary Target

5-aminolevulinate synthase, nonspecific, mitochondrial

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Highest Phase

Approved

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Approval Year

1962

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Condition

Pain

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Treatment Modality

Preventing

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Originator

Endo Laboratories

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Substance Class

Chemical

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Code System

CAS

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ChEMBL

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EPA CompTox

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EVMPD

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FDA UNII

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Substance Form

Principal Form

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Salts, Hydrates, Esters, etc.

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PYRROCAINE

9D47L94CPW

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Status:

US Previously Marketed

First approved in 1962

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

5-aminolevulinate synthase, nonspecific, mitochondrial

Conditions:

Pyrrocaine is the amide local anesthetics. It is metabolized to 2,6-xylidine. It was used mainly as an infiltration and nerve block dental anesthetic in the 1960s and favored due to its rapid onset. The potency of pyrrocaine equals that of lidocaine ...

in both sensory and motor nerve blocking. Pyrrocaine provided to be somewhat less toxic than lidocaine. No methemoglobinemia was clinically observed. It has been classified as unsafe for use in acute porphyria. There is no evidence that it is currently used commercially.

PYRROCAINE HYDROCHLORIDE

9CST8J378F

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Status:

US Previously Marketed

First approved in 1962

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

5-aminolevulinate synthase, nonspecific, mitochondrial

Conditions:

Pyrrocaine is the amide local anesthetics. It is metabolized to 2,6-xylidine. It was used mainly as an infiltration and nerve block dental anesthetic in the 1960s and favored due to its rapid onset. The potency of pyrrocaine equals that of lidocaine ...

in both sensory and motor nerve blocking. Pyrrocaine provided to be somewhat less toxic than lidocaine. No methemoglobinemia was clinically observed. It has been classified as unsafe for use in acute porphyria. There is no evidence that it is currently used commercially.

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