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US Approved OTC

3

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Sodium channel protein type V alpha subunit

3

Sodium channel protein type X alpha subunit

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Approved

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Approval Year

1930

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Pain

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CNS Penetrant

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CAS

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EPA CompTox

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PUBCHEM

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ATC Level 1

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NERVOUS SYSTEM

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SENSORY ORGANS

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ATC Level 2

ANESTHETICS

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ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.

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ATC Level 3

AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE

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ANESTHETICS, LOCAL

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ATC Level 4

Amides

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Local anesthetics

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DIBUCAINE

L6JW2TJG99

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Status:

US Approved OTC

First marketed in 1930

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel protein type X alpha subunit

Sodium channel protein type V alpha subunit

Conditions:

Dibucaine is used as a local anesthetic for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. Dibucaine is used to temporarily relieve pain and i...

tching due to: hemorrhoids or other anorectal disorders, sunburn, minor burns, minor cuts; scrapes, insect bites, minor skin irritation. This drug acts via blocking of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel blocking. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

DIBUCAINE BENZOATE

J31043J63M

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Status:

US Approved OTC

First marketed in 1930

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel protein type X alpha subunit

Sodium channel protein type V alpha subunit

Conditions:

Dibucaine is used as a local anesthetic for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. Dibucaine is used to temporarily relieve pain and i...

tching due to: hemorrhoids or other anorectal disorders, sunburn, minor burns, minor cuts; scrapes, insect bites, minor skin irritation. This drug acts via blocking of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel blocking. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

DIBUCAINE HYDROCHLORIDE

Z97702A5DG

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Status:

US Approved OTC

First marketed in 1930

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel protein type X alpha subunit

Sodium channel protein type V alpha subunit

Conditions:

Dibucaine is used as a local anesthetic for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. Dibucaine is used to temporarily relieve pain and i...

tching due to: hemorrhoids or other anorectal disorders, sunburn, minor burns, minor cuts; scrapes, insect bites, minor skin irritation. This drug acts via blocking of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel blocking. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

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