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US Approved Rx

4

Possibly Marketed Outside US

2

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Primary Target

Squalene monooxygenase

4

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Highest Phase

Approved

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Approval Year

1992

4

Unknown

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Condition

Onychomycosis

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Treatment Modality

Curative

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CNS Activity

CNS Penetrant

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Originator

Sandoz-Forschungsinstitut

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Avitrol Corporation

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Chemical

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CAS

6

FDA UNII

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PUBCHEM

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ChEMBL

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EPA CompTox

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ATC Level 1

DERMATOLOGICALS

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ANTIFUNGALS FOR DERMATOLOGICAL USE

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ANTIFUNGALS FOR SYSTEMIC USE

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ANTIFUNGALS FOR TOPICAL USE

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ATC Level 4

Antifungals for systemic use

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Other antifungals for topical use

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Salts, Hydrates, Esters, etc.

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Showing 1 - 6 of 6 results

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TERBINAFINE

G7RIW8S0XP

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Status:

US Approved Rx (2007)

First approved in 1992

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Squalene monooxygenase

Conditions:

Terbinafine (brand name Lamisil, Terbisil, Terboderm and others) is an antifungal medication used to treat ringworm and fungal nail infections. Terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the...

fungal cell membrane synthesis pathway. Because terbinafine prevents the conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis. Many side effects and adverse drug reactions have been reported with oral terbinafine hydrochloride possibly due to its extensive biodistribution and the often extended durations involved in antifungal treatment (longer than two months).

AZACOSTEROL

EPT876J73A

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ABSOLUTE)

Azacosterol (Ornitrol, 20,25-diazacholesterol dihydrochloride, SC 12937) is a cholesterol-lowering drug (hypocholesteremic) which was marketed previously but has since been discontinued. Azacosterol is a sterol derivative of cholesterol with two nitr...

ogen atoms replacing two carbon atoms that acts as a hypocholesteremic agent by blocking delta-24-reductase. Azacosterol has the unintended side effect of causing myotonia. It is an avian contraceptive compound, which reduces fertility by inhibiting cholesterol synthesis. Azacosterol is also useful in the control of rodent populations.

TERBINAFINE HYDROCHLORIDE, (Z)-

2H771UZ786

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Status:

US Approved Rx (2007)

First approved in 1992

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Squalene monooxygenase

Conditions:

Terbinafine (brand name Lamisil, Terbisil, Terboderm and others) is an antifungal medication used to treat ringworm and fungal nail infections. Terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the...

fungal cell membrane synthesis pathway. Because terbinafine prevents the conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis. Many side effects and adverse drug reactions have been reported with oral terbinafine hydrochloride possibly due to its extensive biodistribution and the often extended durations involved in antifungal treatment (longer than two months).

TERBINAFINE, (Z)-

S76S370M70

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Status:

US Approved Rx (2007)

First approved in 1992

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Squalene monooxygenase

Conditions:

Terbinafine (brand name Lamisil, Terbisil, Terboderm and others) is an antifungal medication used to treat ringworm and fungal nail infections. Terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the...

fungal cell membrane synthesis pathway. Because terbinafine prevents the conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis. Many side effects and adverse drug reactions have been reported with oral terbinafine hydrochloride possibly due to its extensive biodistribution and the often extended durations involved in antifungal treatment (longer than two months).

TERBINAFINE HYDROCHLORIDE

012C11ZU6G

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Status:

US Approved Rx (2007)

First approved in 1992

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Squalene monooxygenase

Conditions:

Terbinafine (brand name Lamisil, Terbisil, Terboderm and others) is an antifungal medication used to treat ringworm and fungal nail infections. Terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the...

fungal cell membrane synthesis pathway. Because terbinafine prevents the conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis. Many side effects and adverse drug reactions have been reported with oral terbinafine hydrochloride possibly due to its extensive biodistribution and the often extended durations involved in antifungal treatment (longer than two months).

AZACOSTEROL HYDROCHLORIDE

B32804UAUQ

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Search for Structure

Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ABSOLUTE)

Azacosterol (Ornitrol, 20,25-diazacholesterol dihydrochloride, SC 12937) is a cholesterol-lowering drug (hypocholesteremic) which was marketed previously but has since been discontinued. Azacosterol is a sterol derivative of cholesterol with two nitr...

ogen atoms replacing two carbon atoms that acts as a hypocholesteremic agent by blocking delta-24-reductase. Azacosterol has the unintended side effect of causing myotonia. It is an avian contraceptive compound, which reduces fertility by inhibiting cholesterol synthesis. Azacosterol is also useful in the control of rodent populations.

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