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US Approved OTC

6

US Approved Rx

3

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Primary Target

Histamine H1 receptor

6

Plasmodium falciparum (isolate K1 / Thailand)

6

Sodium-dependent dopamine transporter

6

Sodium-dependent serotonin transporter

6

Alpha-1-antichymotrypsin

3

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Highest Phase

Approved

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Approval Year

1947

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1949

6

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Condition

Allergic rhinitis

6

Pyridoxine deficiency

3

Pyridoxine-dependent epilepsy

3

West syndrome

3

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Treatment Modality

Primary

9

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CNS Activity

CNS Active

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Originator

Shering

6

Wm. S. Merrell

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Chemical

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CAS

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FDA UNII

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PUBCHEM

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EPA CompTox

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SMS_ID

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

1

ANTIINFECTIVES FOR SYSTEMIC USE

1

RESPIRATORY SYSTEM

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ATC Level 2

ANTIHISTAMINES FOR SYSTEMIC USE

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ANTIMYCOBACTERIALS

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VITAMINS

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ATC Level 3

ANTIHISTAMINES FOR SYSTEMIC USE

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DRUGS FOR TREATMENT OF TUBERCULOSIS

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OTHER PLAIN VITAMIN PREPARATIONS

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ATC Level 4

Combinations of drugs for treatment of tuberculosis

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Other plain vitamin preparations

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Substituted alkylamines

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Showing 1 - 9 of 9 results

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PYRIDOXINE

KV2JZ1BI6Z

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Status:

US Approved Rx (2013)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Alpha-1-antichymotrypsin

Oxidative Stress

Conditions:

Pyridoxine deficiency

Pyridoxine-dependent epilepsy

Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in thos...

e receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities. Used for the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.

CHLORPHENIRAMINE

3U6IO1965U

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Status:

US Approved OTC

First approved in 1949

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Plasmodium falciparum (isolate K1 / Thailand)

Histamine H1 receptor

Sodium-dependent serotonin transporter

Sodium-dependent dopamine transporter

Conditions:

Allergic rhinitis

Chlorpheniramine is an antihistamine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Chlorpheniramine...

is used for relieving symptoms of sinus congestion, sinus pressure, runny nose, watery eyes, itching of the nose and throat, and sneezing due to upper respiratory infections (eg, colds), allergies, and hay fever. In addition to being a histamine H1 receptor (HRH1) antagonist, chlorphenamine has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI.

PYRIDOXINE DIPALMITATE

HB49XCT029

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Status:

US Approved Rx (2013)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Alpha-1-antichymotrypsin

Oxidative Stress

Conditions:

Pyridoxine deficiency

Pyridoxine-dependent epilepsy

Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in thos...

e receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities. Used for the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.

PYRIDOXINE HYDROCHLORIDE

68Y4CF58BV

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Status:

US Approved Rx (2013)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Alpha-1-antichymotrypsin

Oxidative Stress

Conditions:

Pyridoxine deficiency

Pyridoxine-dependent epilepsy

Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in thos...

e receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities. Used for the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.

CHLORPHENIRAMINE TANNATE

72JT935YTT

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Status:

US Approved OTC

First approved in 1949

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Plasmodium falciparum (isolate K1 / Thailand)

Histamine H1 receptor

Sodium-dependent serotonin transporter

Sodium-dependent dopamine transporter

Conditions:

Allergic rhinitis

Chlorpheniramine is an antihistamine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Chlorpheniramine...

is used for relieving symptoms of sinus congestion, sinus pressure, runny nose, watery eyes, itching of the nose and throat, and sneezing due to upper respiratory infections (eg, colds), allergies, and hay fever. In addition to being a histamine H1 receptor (HRH1) antagonist, chlorphenamine has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI.

CHLORPHENIRAMINE GLUCONATE

79YPK3BAIT

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Status:

US Approved OTC

First approved in 1949

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Plasmodium falciparum (isolate K1 / Thailand)

Histamine H1 receptor

Sodium-dependent serotonin transporter

Sodium-dependent dopamine transporter

Conditions:

Allergic rhinitis

Chlorpheniramine is an antihistamine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Chlorpheniramine...

is used for relieving symptoms of sinus congestion, sinus pressure, runny nose, watery eyes, itching of the nose and throat, and sneezing due to upper respiratory infections (eg, colds), allergies, and hay fever. In addition to being a histamine H1 receptor (HRH1) antagonist, chlorphenamine has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI.

CHLORPHENIRAMINE HYDROCHLORIDE

5S6VUP419V

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Status:

US Approved OTC

First approved in 1949

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Plasmodium falciparum (isolate K1 / Thailand)

Histamine H1 receptor

Sodium-dependent serotonin transporter

Sodium-dependent dopamine transporter

Conditions:

Allergic rhinitis

Chlorpheniramine is an antihistamine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Chlorpheniramine...

is used for relieving symptoms of sinus congestion, sinus pressure, runny nose, watery eyes, itching of the nose and throat, and sneezing due to upper respiratory infections (eg, colds), allergies, and hay fever. In addition to being a histamine H1 receptor (HRH1) antagonist, chlorphenamine has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI.

CHLORPHENIRAMINE MALEATE

V1Q0O9OJ9Z

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Status:

US Approved OTC

First approved in 1949

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Plasmodium falciparum (isolate K1 / Thailand)

Histamine H1 receptor

Sodium-dependent serotonin transporter

Sodium-dependent dopamine transporter

Conditions:

Allergic rhinitis

Chlorpheniramine is an antihistamine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Chlorpheniramine...

is used for relieving symptoms of sinus congestion, sinus pressure, runny nose, watery eyes, itching of the nose and throat, and sneezing due to upper respiratory infections (eg, colds), allergies, and hay fever. In addition to being a histamine H1 receptor (HRH1) antagonist, chlorphenamine has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI.

CHLORPHENIRAMINE STEARATE

5J341Q2P1E

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Status:

US Approved OTC

First approved in 1949

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Plasmodium falciparum (isolate K1 / Thailand)

Histamine H1 receptor

Sodium-dependent serotonin transporter

Sodium-dependent dopamine transporter

Conditions:

Allergic rhinitis

Chlorpheniramine is an antihistamine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Chlorpheniramine...

is used for relieving symptoms of sinus congestion, sinus pressure, runny nose, watery eyes, itching of the nose and throat, and sneezing due to upper respiratory infections (eg, colds), allergies, and hay fever. In addition to being a histamine H1 receptor (HRH1) antagonist, chlorphenamine has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI.

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