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US Previously Marketed

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Primary Target

peptidoglycan biosynthetic process

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Highest Phase

Approved

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Approval Year

1960

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Condition

Bacterial infections

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Treatment Modality

Curative

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CNS Activity

CNS Active

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Originator

Doyle, F.P.

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Chemical

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ANTIINFECTIVES FOR SYSTEMIC USE

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ANTIBACTERIALS FOR SYSTEMIC USE

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ATC Level 3

BETA-LACTAM ANTIBACTERIALS, PENICILLINS

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ATC Level 4

Beta-lactamase resistant penicillins

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Salts, Hydrates, Esters, etc.

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METHICILLIN

Q91FH1328A

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Status:

US Previously Marketed

First approved in 1960

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

peptidoglycan biosynthetic process

Conditions:

Bacterial infections

Methicillin sodium anhydrous is a sodium salt of methicillin (methicillin). Methicillin is an antibiotic formerly used in the treatment of bacterial infections caused by organisms of the genus Staphylococcus. Methicillin is a semisynthetic derivative...

of penicillin. It was first produced in the late 1950s and was developed as a type of antibiotic called penicillinase-resistant penicillin—it contained a modification to the original penicillin structure that made it resistant to a bacterial enzyme called penicillinase (beta-lactamase). Compared to other penicillins that face antimicrobial resistance due to β-lactamase, it is less active, can be administered only parenterally, and has a higher frequency of interstitial nephritis, an otherwise-rare adverse effect of penicillins. However, the selection of meticillin depended on the outcome of susceptibility testing of the sampled infection, and since it is no longer produced, it is also not routinely tested for anymore.

METHICILLIN SODIUM ANHYDROUS

NBQ410S76Y

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Status:

US Previously Marketed

First approved in 1960

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

peptidoglycan biosynthetic process

Conditions:

Bacterial infections

Methicillin sodium anhydrous is a sodium salt of methicillin (methicillin). Methicillin is an antibiotic formerly used in the treatment of bacterial infections caused by organisms of the genus Staphylococcus. Methicillin is a semisynthetic derivative...

of penicillin. It was first produced in the late 1950s and was developed as a type of antibiotic called penicillinase-resistant penicillin—it contained a modification to the original penicillin structure that made it resistant to a bacterial enzyme called penicillinase (beta-lactamase). Compared to other penicillins that face antimicrobial resistance due to β-lactamase, it is less active, can be administered only parenterally, and has a higher frequency of interstitial nephritis, an otherwise-rare adverse effect of penicillins. However, the selection of meticillin depended on the outcome of susceptibility testing of the sampled infection, and since it is no longer produced, it is also not routinely tested for anymore.

METHICILLIN SODIUM

AO9YF4MN30

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Status:

US Previously Marketed

First approved in 1960

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

peptidoglycan biosynthetic process

Conditions:

Bacterial infections

Methicillin sodium anhydrous is a sodium salt of methicillin (methicillin). Methicillin is an antibiotic formerly used in the treatment of bacterial infections caused by organisms of the genus Staphylococcus. Methicillin is a semisynthetic derivative...

of penicillin. It was first produced in the late 1950s and was developed as a type of antibiotic called penicillinase-resistant penicillin—it contained a modification to the original penicillin structure that made it resistant to a bacterial enzyme called penicillinase (beta-lactamase). Compared to other penicillins that face antimicrobial resistance due to β-lactamase, it is less active, can be administered only parenterally, and has a higher frequency of interstitial nephritis, an otherwise-rare adverse effect of penicillins. However, the selection of meticillin depended on the outcome of susceptibility testing of the sampled infection, and since it is no longer produced, it is also not routinely tested for anymore.

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