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US Approved Rx

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Primary Target

3-hydroxy-3-methylglutaryl-coenzyme A reductase

6

Cytochrome P450 3A4

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HMG-CoA reductase

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Solute carrier organic anion transporter family member 1B1

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Solute carrier organic anion transporter family member 3A1

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Coronary heart disease mortality and cardiovascular events

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Homozygous and heterozygous familial hypercholesterolemia

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BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS

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Dipeptidyl peptidase 4 (DPP-4) inhibitors

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Showing 1 - 7 of 7 results

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TENIVASTATIN

9L6M5TH46B

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Status:

US Approved Rx (2016)

First approved in 1991

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Solute carrier organic anion transporter family member 3A1

Solute carrier organic anion transporter family member 1B1

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Cytochrome P450 3A4

HMG-CoA reductase

Conditions:

Coronary heart disease mortality and cardiovascular events

Homozygous and heterozygous familial hypercholesterolemia

Simvastatin is a HMG-CoA Reductase Inhibitor that is FDA approved for the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It reduces levels of "bad" cholesterol (low-de...

nsity lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Common adverse reactions include abdominal pain, constipation, nausea, headache, upper respiratory infection. Cases of myopathy/rhabdomyolysis have been observed with simvastatin co-administered with lipid-modifying doses ( ≥ 1 g/day niacin) of niacin-containing products. The risk of myopathy, including rhabdomyolysis, is increased by concomitant administration of amiodarone, dronedarone, ranolazine, or calcium channel blockers such as verapamil, diltiazem, or amlodipine.

STATINE

YTC77XR1EK

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

SIMVASTATIN

AGG2FN16EV

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Status:

US Approved Rx (2016)

First approved in 1991

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Solute carrier organic anion transporter family member 3A1

Solute carrier organic anion transporter family member 1B1

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Cytochrome P450 3A4

HMG-CoA reductase

Conditions:

Coronary heart disease mortality and cardiovascular events

Homozygous and heterozygous familial hypercholesterolemia

Simvastatin is a HMG-CoA Reductase Inhibitor that is FDA approved for the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It reduces levels of "bad" cholesterol (low-de...

nsity lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Common adverse reactions include abdominal pain, constipation, nausea, headache, upper respiratory infection. Cases of myopathy/rhabdomyolysis have been observed with simvastatin co-administered with lipid-modifying doses ( ≥ 1 g/day niacin) of niacin-containing products. The risk of myopathy, including rhabdomyolysis, is increased by concomitant administration of amiodarone, dronedarone, ranolazine, or calcium channel blockers such as verapamil, diltiazem, or amlodipine.

TENIVASTATIN SODIUM

2L6JSY5YGL

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Status:

US Approved Rx (2016)

First approved in 1991

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Solute carrier organic anion transporter family member 3A1

Solute carrier organic anion transporter family member 1B1

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Cytochrome P450 3A4

HMG-CoA reductase

Conditions:

Coronary heart disease mortality and cardiovascular events

Homozygous and heterozygous familial hypercholesterolemia

Simvastatin is a HMG-CoA Reductase Inhibitor that is FDA approved for the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It reduces levels of "bad" cholesterol (low-de...

nsity lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Common adverse reactions include abdominal pain, constipation, nausea, headache, upper respiratory infection. Cases of myopathy/rhabdomyolysis have been observed with simvastatin co-administered with lipid-modifying doses ( ≥ 1 g/day niacin) of niacin-containing products. The risk of myopathy, including rhabdomyolysis, is increased by concomitant administration of amiodarone, dronedarone, ranolazine, or calcium channel blockers such as verapamil, diltiazem, or amlodipine.

TENIVASTATIN AMMONIUM

76RD797JAX

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Status:

US Approved Rx (2016)

First approved in 1991

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Solute carrier organic anion transporter family member 3A1

Solute carrier organic anion transporter family member 1B1

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Cytochrome P450 3A4

HMG-CoA reductase

Conditions:

Coronary heart disease mortality and cardiovascular events

Homozygous and heterozygous familial hypercholesterolemia

Simvastatin is a HMG-CoA Reductase Inhibitor that is FDA approved for the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It reduces levels of "bad" cholesterol (low-de...

nsity lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Common adverse reactions include abdominal pain, constipation, nausea, headache, upper respiratory infection. Cases of myopathy/rhabdomyolysis have been observed with simvastatin co-administered with lipid-modifying doses ( ≥ 1 g/day niacin) of niacin-containing products. The risk of myopathy, including rhabdomyolysis, is increased by concomitant administration of amiodarone, dronedarone, ranolazine, or calcium channel blockers such as verapamil, diltiazem, or amlodipine.

TENIVASTATIN CALCIUM

YNO268EI8T

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Status:

US Approved Rx (2016)

First approved in 1991

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Solute carrier organic anion transporter family member 3A1

Solute carrier organic anion transporter family member 1B1

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Cytochrome P450 3A4

HMG-CoA reductase

Conditions:

Coronary heart disease mortality and cardiovascular events

Homozygous and heterozygous familial hypercholesterolemia

Simvastatin is a HMG-CoA Reductase Inhibitor that is FDA approved for the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It reduces levels of "bad" cholesterol (low-de...

nsity lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Common adverse reactions include abdominal pain, constipation, nausea, headache, upper respiratory infection. Cases of myopathy/rhabdomyolysis have been observed with simvastatin co-administered with lipid-modifying doses ( ≥ 1 g/day niacin) of niacin-containing products. The risk of myopathy, including rhabdomyolysis, is increased by concomitant administration of amiodarone, dronedarone, ranolazine, or calcium channel blockers such as verapamil, diltiazem, or amlodipine.

TENIVASTATIN CALCIUM HYDRATE

QSL5L73L0O

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Status:

US Approved Rx (2016)

First approved in 1991

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Solute carrier organic anion transporter family member 3A1

Solute carrier organic anion transporter family member 1B1

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Cytochrome P450 3A4

HMG-CoA reductase

Conditions:

Coronary heart disease mortality and cardiovascular events

Homozygous and heterozygous familial hypercholesterolemia

Simvastatin is a HMG-CoA Reductase Inhibitor that is FDA approved for the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It reduces levels of "bad" cholesterol (low-de...

nsity lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Common adverse reactions include abdominal pain, constipation, nausea, headache, upper respiratory infection. Cases of myopathy/rhabdomyolysis have been observed with simvastatin co-administered with lipid-modifying doses ( ≥ 1 g/day niacin) of niacin-containing products. The risk of myopathy, including rhabdomyolysis, is increased by concomitant administration of amiodarone, dronedarone, ranolazine, or calcium channel blockers such as verapamil, diltiazem, or amlodipine.

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