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Possibly Marketed Outside US

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Primary Target

Delta(14)-sterol reductase

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Δ7-cholestenol Δ7-Δ8-isomerase (fungi)

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Highest Phase

Approved

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Approval Year

Unknown

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Condition

Dermatomycosis

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Onychomycosis

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Treatment Modality

Curative

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Originator

Hoffman-La Roche

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Chemical

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CAS

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ChEMBL

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DRUG BANK

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EPA CompTox

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ATC Level 1

DERMATOLOGICALS

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ANTIFUNGALS FOR DERMATOLOGICAL USE

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ATC Level 3

ANTIFUNGALS FOR TOPICAL USE

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ATC Level 4

Other antifungals for topical use

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Substance Form

Principal Form

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Salts, Hydrates, Esters, etc.

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AMOROLFINE

AB0BHP2FH0

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Δ7-cholestenol Δ7-Δ8-isomerase (fungi)

Delta(14)-sterol reductase

Conditions:

Amorolfine (or amorolfin), is a morpholine antifungal drug with broad spectrum of activity. Its fungicidal action is based on an alteration of the fungal cell membrane targeted primarily on sterol biosynthesis. Amorolfine is administered as a nail la...

cquer in patients suffering from onychomycosis, as a cream in patients suffering from dermatomycosis. Amorolfine is well tolerated. The local adverse effects observed were mainly burning and itching.

AMOROLFINE HYDROCHLORIDE

741YH7379H

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (MIXED)

Targets:

Δ7-cholestenol Δ7-Δ8-isomerase (fungi)

Delta(14)-sterol reductase

Conditions:

Amorolfine (or amorolfin), is a morpholine antifungal drug with broad spectrum of activity. Its fungicidal action is based on an alteration of the fungal cell membrane targeted primarily on sterol biosynthesis. Amorolfine is administered as a nail la...

cquer in patients suffering from onychomycosis, as a cream in patients suffering from dermatomycosis. Amorolfine is well tolerated. The local adverse effects observed were mainly burning and itching.

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